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View Structure Prediction Details

Protein: krimp-PA
Organism: Drosophila melanogaster
Length: 746 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for krimp-PA.

Description E-value Query
Range
Subject
Range
gi|25012741 - gi|25012741|gb|AAN71463.1| RE66405p [Drosophila melanogaster]
559.0 [0..1] [656..1]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLEDISMIM KLFDSNMHKL QGNLRSYQTE MHQIHKELTE KLSHADLLYR SLIPLHDHLV  60
   61 ASLSEVNAHV MKLNVQLHIN R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [82-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSVRLGDYEY YEKSIDNPYS SIRSGLQAIE KPGCAEAICQ SSKPAFVECL PSSTSEEVPV  60
   61 VAVQEASSTN QLDAISVVNE NLSEERDATP QPLAVSKNME ETMPSNPFHE QLEGSLEEIP 120
  121 VGSKIVVETE KANNPV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [218-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSEASAPATS DNQSLLAAKQ GTQTIGTGIC NKISKSTINM PNNWQLENPT EVTAASIEKV  60
   61 NKLPKSPRNR FLLPPKGGTE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [298-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTRRDIYNQI LKDMAAFPEN TIVTAVLASV DVTDNCAYVA KWDESSDRIK KVLQRQLPLQ  60
   61 ELDQLPDYGD IFAVLDSINN IITRITINSS SAGGGYDAYL IDFGEHIHFD GNETIFKLPD 120
  121 DIKRLPAQAI RCDLINCDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 2d9tA
Description: No description for 2d9tA was found.

Predicted functions:

Term Confidence Notes
binding 2.60998973020963 bayes_pls_golite062009
transcription repressor activity 2.33861387740649 bayes_pls_golite062009
transcription regulator activity 2.19872709046627 bayes_pls_golite062009
protein binding 1.76914488602752 bayes_pls_golite062009
histone methyltransferase activity 1.68557512550835 bayes_pls_golite062009
histone binding 1.42699325473147 bayes_pls_golite062009
DNA binding 1.36613258095775 bayes_pls_golite062009
nucleic acid binding 1.33146849973268 bayes_pls_golite062009
lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
chromatin binding 0.98282919061767 bayes_pls_golite062009
protein methyltransferase activity 0.937656130642761 bayes_pls_golite062009
transcription corepressor activity 0.858902267969751 bayes_pls_golite062009
transcription factor binding 0.80529345551372 bayes_pls_golite062009
transcription cofactor activity 0.65687417812623 bayes_pls_golite062009
transcription factor activity 0.453415046852858 bayes_pls_golite062009
methylated histone residue binding 0.35315659904958 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [437-553]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANMHCFVNTY IKIRVHENNN STLVAEPVID RLSRPTKTNT TKYPAGITED DMAMLNEIDE  60
   61 STSDPLKAVL GFRPKDEQRI CRHYDPKLNG CFKGNNCRFA HEPFAPNGAT KDVELAR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.18
Match: 2d9mA
Description: No description for 2d9mA was found.

Predicted Domain #6
Region A:
Residues: [554-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALPETIFDTT VHFEIGSIVG ILITFINGPT EVYGQFLDGS PPLVWDKKDV PENKRTFKSK  60
   61 PRLLDIVLAL YSDGCFYRAQ IIDEFPSEYM IFYVDYGNTE FVPLSCLAPC ENVDSFKPHR 120
  121 VFSFHIEGIV RSKNLTHQKT IECIEYLKSK LLNTEMNVHL VQRLPDGFLI RFLDDWKYIP 180
  181 EQLLQRNYAQ VSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 2hqeA
Description: No description for 2hqeA was found.

Predicted functions:

Term Confidence Notes
binding 2.60998973020963 bayes_pls_golite062009
transcription repressor activity 2.33861387740649 bayes_pls_golite062009
transcription regulator activity 2.19872709046627 bayes_pls_golite062009
protein binding 1.76914488602752 bayes_pls_golite062009
histone methyltransferase activity 1.68557512550835 bayes_pls_golite062009
histone binding 1.42699325473147 bayes_pls_golite062009
DNA binding 1.36613258095775 bayes_pls_golite062009
nucleic acid binding 1.33146849973268 bayes_pls_golite062009
lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
chromatin binding 0.98282919061767 bayes_pls_golite062009
protein methyltransferase activity 0.937656130642761 bayes_pls_golite062009
transcription corepressor activity 0.858902267969751 bayes_pls_golite062009
transcription factor binding 0.80529345551372 bayes_pls_golite062009
transcription cofactor activity 0.65687417812623 bayes_pls_golite062009
transcription factor activity 0.453415046852858 bayes_pls_golite062009
methylated histone residue binding 0.35315659904958 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle