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Protein Overview: Iap2-PA, Iap2-PB

General Information:
Name(s) found: Iap2-PB / FBpp0086432 [FlyBase]
Iap2-PA / FBpp0086431 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene Inhibitor of apoptosis 2 is referred to in FlyBase by the symbol Dmel\Iap2 (CG8293, FBgn0015247). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11819675..11822330. It has the cytological map location 52D2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding; zinc ion binding. There is experimental evidence that it is involved in the biological process</span>: anti-apoptosis; sensory organ development; defense response to Gram-negative bacterium; antimicrobial humoral response. 22 alleles are reported. The phenotype of these alleles is annotated with: pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Inhibitor of apoptosis 2 is referred to in FlyBase by the symbol Dmel\Iap2 (CG8293, FBgn0015247). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11819675..11822330. It has the cytological map location 52D2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding; zinc ion binding. There is experimental evidence that it is involved in the biological process</span>: anti-apoptosis; sensory organ development; defense response to Gram-negative bacterium; antimicrobial humoral response. 22 alleles are reported. The phenotype of these alleles is annotated with: pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 498 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: anti-apoptosis [IDA][ISS][NAS][TAS]
    defense response to Gram-negative bacterium [IMP]
    antimicrobial humoral response [IMP]
    sensory organ development [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH VRIDRWEYGD  60
   61 QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDNEGNSVVD SPESCSCPDL LLEANRLVTF 120
  121 KDWPNPNITP QALAKAGFYY LNRLDHVKCV WCNGVIAKWE KNDNAFEEHK RFFPQCPRVQ 180
  181 MGPLIEFATG KNLDELGIQP TTLPLRPKYA CVDARLRTFT DWPISNIQPA SALAQAGLYY 240
  241 QKIGDQVRCF HCNIGLRSWQ KEDEPWFEHA KWSPKCQFVL LAKGPAYVSE VLATTAANAS 300
  301 SQPATAPAPT LQADVLMDEA PAKEALALGI DGGVVRNAIQ RKLLSSGCAF STLDELLHDI 360
  361 FDDAGAGAAL EVREPPEPSA PFIEPCQATT SKAASVPIPV ADSIPAKPQA AEAVANISKI 420
  421 TDEIQKMSVA TPNGNLSLEE ENRQLKDARL CKVCLDEEVG VVFLPCGHLA TCNQCAPSVA 480
  481 NCPMCRADIK GFVRTFLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 27.522879 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
    2 View Details [94..193] PSI-BLAST 24.0 BIR2 domain of DIAP1
    3 View Details [194..305] PSI-BLAST 23.39794 2MIHB/C-IAP-1
    4 View Details [306..498] PSI-BLAST 8.39794 Cbl; N-terminal domain of cbl (N-cbl); CBL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.24291003560785 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • microtubule binding
    		•  1.03349057074077 bayes_pls_golite062009
  • tubulin binding
    		•  1.0137804715367 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.515008648709161 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0431703651486497 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0242766345667098 bayes_pls_golite062009
  • cofactor binding
    		•  0.0023150693787124 bayes_pls_golite062009
    2
    Term Confidence Notes
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.24291003560785 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • microtubule binding
    		•  1.03349057074077 bayes_pls_golite062009
  • tubulin binding
    		•  1.0137804715367 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.515008648709161 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0431703651486497 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0242766345667098 bayes_pls_golite062009
  • cofactor binding
    		•  0.0023150693787124 bayes_pls_golite062009
    3
    Term Confidence Notes
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.24291003560785 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • microtubule binding
    		•  1.03349057074077 bayes_pls_golite062009
  • tubulin binding
    		•  1.0137804715367 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.515008648709161 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0431703651486497 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0242766345667098 bayes_pls_golite062009
  • cofactor binding
    		•  0.0023150693787124 bayes_pls_golite062009
    4
    Term Confidence Notes
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.92323609459085 bayes_pls_golite062009
  • signal transducer activity
    		•  2.92323609459085 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.18707666182719 bayes_pls_golite062009
  • receptor binding
    		•  1.09099343809921 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.353553274217716 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.352421112301971 bayes_pls_golite062009
  • protein complex binding
    		•  0.32615263839176 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle