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Protein Overview: Poxn-PA, FBpp0302942

General Information:
Name(s) found: FBpp0302942 [FlyBase]
Poxn-PA / FBpp0086446 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=2R:complement(11714535..11715578,11717671..11717750,11717820..11717960,11718536..11718548); ID=FBpp0302942; name=Poxn-PB; parent=FBgn0003130,FBtr0329908; dbxref=FlyBase:FBpp0302942,FlyBase_Annotation_IDs:CG8246-PB,REFSEQ:NP_001261016,GB_protein:AGB93548; MD5=0d794add7a1ca910bcb42d9258ea29df; length=425; release=r5.56; species=Dmel; [FlyBase]
  • The gene Pox neuro is referred to in FlyBase by the symbol Dmel\Poxn (CG8246, FBgn0003130). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11714198..11722280. It has the cytological map location 52C7. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: sensory organ development; antennal morphogenesis; adult feeding behavior; imaginal disc-derived wing morphogenesis; imaginal disc-derived leg morphogenesis; male courtship behavior. 36 alleles are reported. The phenotypes of these alleles are annotated with 49 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; adult mesothoracic segment; gustatory sensory organ; external compound sense organ; antennal segment; metatarsus; appendage segment; v'es2 neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: imaginal disc-derived leg morphogenesis [IMP]
    nervous system development [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    male courtship behavior [IMP]
    regulation of transcription, DNA-dependent [ISS][NAS]
    antennal morphogenesis [IMP]
    adult feeding behavior [IMP]
    regulation of transcription [IEA]
    sensory organ development [IMP][NAS]
    Molecular Function: transcription factor activity [ISS]
    transcription regulator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHTGQAGVN QLGGVFVNGR PLPDCVRRRI VDLALCGVRP CDISRQLLVS HGCVSKILTR  60
   61 FYETGSIRPG SIGGSKTKQV ATPTVVKKII RLKEENSGMF AWEIREQLQQ QRVCDPSSVP 120
  121 SISSINRILR NSGLWTDEMT SSQQNAAAAA AAAAAAAHQA GSGPSNGYGG QAPPPPVTVA 180
  181 PPTPAATPSI ARYAKPPALM MNSAGEMPIK PAPKMPPSMG HGHSHGLNPN VSGLDLSYSA 240
  241 LHKHWLWNPS LLYYTQAHIQ AQAAASGGQF LPYAGGYLPH AMAAAAASST SALGGFTKSE 300
  301 SSIDLSTPGA AGDALSDCDS GKSSPAALSL TASGGGNGAG SAPEASPGST LSHSRKRNPY 360
  361 SIEELLKKPE KRLRLDSNRL ECLESSSCES SQDSPVAPPL ETPEDEDPAE AEEEQEEEDS 420
  421 VEVVN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 50.522879 Pax-5
    2 View Details [140..232] deduced N/A No confident structure predictions are available.
    3 View Details [233..425] MSA 8.279996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle