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Protein Overview: Dh44-R1-PA

General Information:
Name(s) found: Dh44-R1-PA / FBpp0086614 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Diuretic hormone 44 receptor 1 is referred to in FlyBase by the symbol Dmel\Dh44-R1 (CG8422, FBgn0033932). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10265630..10272864. It has the cytological map location 50F8-50F9. There is experimental evidence that it has the molecular function</span>: diuretic hormone receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [ISS]
    Biological Process: G-protein coupled receptor protein signaling pathway [IEA][ISS]
    cell surface receptor linked signaling pathway [IEA]
    Molecular Function: G-protein coupled receptor activity [IEA]
    neuropeptide receptor activity [ISS]
    calcitonin receptor activity [ISS]
    neuropeptide hormone activity [NAS]
    diuretic hormone receptor activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDHNHIDSV NASGSDPLLD LHNLDGIGES VELQCLVQEH IEASTYGNDS GHCLTQFDSI  60
   61 LCWPRTARGT LAVLQCMDEL QGIHYDSSKN ATRFCHANGT WEKYTNYDAC AHLPAPESVP 120
  121 EFEVIVELPT IIYYIGYTLS LVSLSLALIV FAYFKELRCL RNTIHANLFF TYIMSALFWI 180
  181 LLLSVQISIR SGVGSCIALI TLFHFFTLTN FFWMLVEGLY LYMLVVKTFS GDNLRFNIYA 240
  241 SIGWGGPALF VVTWAVAKSL TVTYSTPEKY EINCPWMQET HVDWIYQGPV CAVLIINLTF 300
  301 LLRIMWVLIT KLRSANTVET RQYRKAAKAL LVLIPLFGIT YLVVLAGPSE SGLMGHMFAV 360
  361 LRAVLLSTQG FSVSLFYCFL NSEVRNALRH HISTWRDTRT IQLNQNRRYT TKSFSKGGGS 420
  421 PRAESMRPLT SYYGRGKRES CVSSATTTTL VGQHAPLSLH RGSNNALHTM PTLAANAMSS 480
  481 GSTLSVMPRA ISPLMRQGLE ENSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] PSI-BLAST 19.69897 No description for 2jodA was found.
    2 View Details [106..414] PSI-BLAST 35.69897 Rhodopsin
    3 View Details [415..504] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  7.11838006478957 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.41031049482732 bayes_pls_golite062009
  • receptor activity
    		•  5.12318570081263 bayes_pls_golite062009
  • signal transducer activity
    		•  4.16951678107564 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.16951678107564 bayes_pls_golite062009
  • pituitary adenylate cyclase-activating polypeptide receptor activity
    		•  2.36627671354861 bayes_pls_golite062009
  • binding
    		•  1.48001943103409 bayes_pls_golite062009
  • peptide binding
    		•  1.37672683415634 bayes_pls_golite062009
  • secretin receptor activity
    		•  1.22301183149097 bayes_pls_golite062009
  • growth hormone-releasing hormone receptor activity
    		•  0.621179725102141 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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