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Protein Overview: mam-PB, mam-PA, ...

General Information:
Name(s) found: FBpp0308978 [FlyBase]
mam-PB / FBpp0086723 [FlyBase]
mam-PA / FBpp0086722 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • type=protein; loc=2R:join(9897991..9898686,9926215..9928284,9943268..9943553,9943622..9944701,9944767..9945419); ID=FBpp0308978; name=mam-PD; parent=FBgn0002643,FBtr0339956; dbxref=FlyBase:FBpp0308978,FlyBase_Annotation_IDs:CG8118-PD; MD5=37ee6ee75a36e25f599f12a853f86a8c; length=1594; release=r5.56; species=Dmel; [FlyBase]
  • The gene mastermind is referred to in FlyBase by the symbol Dmel\mam (CG8118, FBgn0002643). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9878686..9947861. It has the cytological map location 50C23-50D3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: germ-line stem cell maintenance; heart morphogenesis; apposition of dorsal and ventral imaginal disc-derived wing surfaces; mesodermal cell fate determination; imaginal disc-derived wing margin morphogenesis; somatic stem cell maintenance; bristle morphogenesis; imaginal disc-derived wing morphogenesis; asymmetric cell division. 193 alleles are reported. The phenotypes of these alleles are annotated with 50 unique terms, many of which group under: organ system; adult segment; embryonic nervous system; adult mesothoracic segment; peripheral nervous system; nervous system; embryonic neuron; embryonic glial cell; germarium; external compound sense organ. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene mastermind is referred to in FlyBase by the symbol Dmel\mam (CG8118, FBgn0002643). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9878686..9947861. It has the cytological map location 50C23-50D3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: germ-line stem cell maintenance; heart morphogenesis; apposition of dorsal and ventral imaginal disc-derived wing surfaces; mesodermal cell fate determination; imaginal disc-derived wing margin morphogenesis; somatic stem cell maintenance; bristle morphogenesis; imaginal disc-derived wing morphogenesis; asymmetric cell division. 193 alleles are reported. The phenotypes of these alleles are annotated with 50 unique terms, many of which group under: organ system; adult segment; embryonic nervous system; adult mesothoracic segment; peripheral nervous system; nervous system; embryonic neuron; embryonic glial cell; germarium; external compound sense organ. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1594 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    nuclear speck [IEA]
    Biological Process: nervous system development [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    asymmetric cell division [IMP]
    imaginal disc-derived wing margin morphogenesis [IMP]
    ectoderm development [TAS]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IEA]
    compound eye development [TAS]
    mesodermal cell fate determination [IMP]
    bristle morphogenesis [IMP]
    heart morphogenesis [IMP]
    Notch signaling pathway [IEA][NAS]
    germ-line stem cell maintenance [IMP]
    somatic stem cell maintenance [IMP]
    Molecular Function: transcription coactivator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAGGLPVFQ SASQAAAVAQ QQQQQQQQQQ QHLNLQLHQQ HLGLHLQQQQ QLQLQQQQHN  60
   61 AQAQQQQIQV QQQQQQQQQQ QQQQHSPYNA NLGATGGIAG ITGGNGAGGP TNPGAVPTAP 120
  121 GDTMPTKRMP VVDRLRRRME NYRRRQTDCV PRYEQAFNTV CEQQNQETTV LQKRFLESKN 180
  181 KRAAKKTDKK LPDPSQQHQQ QQHQQQQQHQ QHQQHQQAQT MLAGQLQSSV HVQQKFLKRP 240
  241 AEDVDNGPDS FEPPHKLPNN NNNSNSNNNN GNANANNGGN GSNTGNNTNN NGNSTNNNGG 300
  301 SNNNGSENLT KFSVEIVQQL EFTTSAANSQ PQQISTNVTV KALTNTSVKS EPGVGGGGGG 360
  361 GGGGGSGNNN NNGGGGGGGN GNNNNNGGDH HQQQHQQQQQ QQGGGLGGLG NNGRGGGPGG 420
  421 MATGPGGVAG GLGGMGMPPN MMSAQQKSAL GNLANLVECK REPDHDFPDL GSLDKDGGGG 480
  481 QFPGFPDLLG DDNSENNDTF KDLINNLQDF NPSFLDGFDE KPLLDIKTED GIKVEPPNAQ 540
  541 DLINSLNVKS EGGLGHGFGG FGLGLDNPGM KMRGGNPGNQ GGFPNGPNGG TGGAPNAGGN 600
  601 GGNSGNLMSE HPLAAQTLKQ MAEQHQHKNA MGGMGGFPRP PHGMNPQQQQ QQQQQQQQQQ 660
  661 AQQQHGQMMG QGQPGRYNDY GGGFPNDFGL GPNGPQQQQQ AQQQQPQQQH LPPQFHQQKG 720
  721 PGPGAGMNVQ QNFLDIKQEL FYSSQNDFDL KRLQQQQAMQ QQQQQQHHQQ QQQQQQPKMG 780
  781 GVPNFNKQQQ QQQVPQQQLQ QQQQQQQQQQ QQQQQQYSPF SNQNPNAAAN FLNCPPRGGP 840
  841 NGNQQPGNLA QQQQQPGAGP QQQQQRGNAA NGQQNNPNAG PGGNTPNAPQ QQQQQSTTTT 900
  901 LQMKQTQQLH ISQQGGGAHG IQVSAGQHLH LSGDMKSNVS VAAQQGVFFS QQQAQQQQQQ 960
  961 QQPGGTNGPN PQQQQQQPHG GNAGGGVGVG VGVGVGNGGP NPGQQQQQPN QNMSNANVPS1020
 1021 DGFSLSQSQS MNFNQQQQQQ AAAQQQQVQP NMRQRQTQAQ AAAAAAAAAA QAQAAANASG1080
 1081 PNVPLMQQPQ VGVGVGVGVG VGVGVGNGGV VGGPGSGGPN NGAMNQMGGP MGGMPGMQMG1140
 1141 GPMNPMQMNP NAAGPTAQQM MMGSGAGGPG QVPGPGQGPN PNQAKFLQQQ QMMRAQAMQQ1200
 1201 QQQHMSGARP PPPEYNATKA QLMQAQMMQQ TVGGGGVGVG GVGVGVGVGG VGGANGGRFP1260
 1261 NSAAQAAAMR RMTQQPIPPS GPMMRPQHAM YMQQHGGAGG GPRTGMGVPY GGGAGGPMGG1320
 1321 PQQQQRPPNV QVTPDGMPMG SQQEWRHMMM TQQQTQMGFG GPGPGGPMRQ GPGGFNGGNF1380
 1381 MPNGAPNGAA GSGPNAGGMM SGPNVPQMQL TPAQMQQQLM RQQQQQQQQQ QQHMGPGAAN1440
 1441 NMQMQQLLQQ QQSGGGGNMM ASQMQMTSMH MTQTQQQITM QQQQQFVQST TTTTHQQQQM1500
 1501 MQMGPGGGGG GGGPGSANNN NGGGGGGAAG GGNSASTIAS ASSISQTINS VVANSNDFGL1560
 1561 EFLDNLPVDS NFSTQDLINS LDNDNFNLQD FNMP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] FFAS03 1.2 crystal structure of the cytotoxic bacterial protein colicin B at 2.5 A resolution
    2 View Details [118..238] PSI-BLAST 5.154902 No description for 2f8xM was found.
    3 View Details [239..327] MSA 1.127996 View MSA. No confident structure predictions are available.
    4 View Details [328..1513] PSI-BLAST 95.69897 No description for 1y0fA was found.
    5 View Details [1514..1594] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.22

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle