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Protein Overview: Aats-phe-PA

General Information:
Name(s) found: Aats-phe-PA / FBpp0086720 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Phenylalanyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-phe (CG13348, FBgn0020766). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9855852..9857407. It has the cytological map location 50C20. Based on sequence similarity, it is predicted to have molecular function</span>: phenylalanine-tRNA ligase activity. There is experimental evidence that it is involved in the biological process</span>: lysosome organization. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS]
    Biological Process: lysosome organization [IMP]
    tRNA processing [IEA]
    phenylalanyl-tRNA aminoacylation [ISS]
    Molecular Function: magnesium ion binding [IEA]
    ATP binding [IEA]
    phenylalanine-tRNA ligase activity [ISS][NAS]
    tRNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLTLRVQGA RHWLKSTRCL ASSAAPAKSP SSPPQLEVSG STYATDGWTN VTPKILSYVG  60
   61 ANKHLQTDHP LSIIRQRIVN YFYGAYRNQR GNPLFSVYDQ MNPVVTVQQN FDNLLIPADH 120
  121 VSRQKSDCYY INQQHLLRAH TTAHQVELIS GGLDNFLVVG EVYRRDEIDS THYPVFHQAD 180
  181 AVRLVTKDKL FERNPGLELF EETWSGTLAD PKLILPSSKF MDQTKQPCHT LEAVKLMEHE 240
  241 MKHVLVGLTK DLFGPRIKYR WVDTYFPFTQ PSWELEIYFK DNWLEVLGCG IMRHEILQRS 300
  301 GVHQSIGYAF GVGLERLAMV LFDIPDIRLF WSNDSGFLSQ FSEKDLHNLP KYKPISHYPQ 360
  361 CTNDLSFWLP QDIEVDAGFS PNDFYDLVRS VAGDMVEQIS LVDKFKHPKT GKSSVCFRIV 420
  421 YRHMERTLTQ AEVNEIHKQI ASASVDSFNV QIR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] PSI-BLAST 59.0 Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS
    2 View Details [333..453] FFAS03 3.98 Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phenylalanine-tRNA ligase activity
    		•  13.8919118344182 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  12.5698315343202 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  12.5698315343202 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  12.5592545638101 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • binding
    		•  0.966824335333342 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • RNA binding
    		•  0.524959231698733 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • protein binding
    		•  0.0804954454681041 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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