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View Structure Prediction Details

Protein: Aats-phe-PA
Organism: Drosophila melanogaster
Length: 453 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Aats-phe-PA.

Description E-value Query
Range
Subject
Range
gi|5656618 - gi|5656618|gb|AAB65750.2| phenylalanyl tRNA synthetase [Drosophila melanogaster]
369.0 [0..1] [453..1]

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Predicted Domain #1
Region A:
Residues: [1-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLTLRVQGA RHWLKSTRCL ASSAAPAKSP SSPPQLEVSG STYATDGWTN VTPKILSYVG  60
   61 ANKHLQTDHP LSIIRQRIVN YFYGAYRNQR GNPLFSVYDQ MNPVVTVQQN FDNLLIPADH 120
  121 VSRQKSDCYY INQQHLLRAH TTAHQVELIS GGLDNFLVVG EVYRRDEIDS THYPVFHQAD 180
  181 AVRLVTKDKL FERNPGLELF EETWSGTLAD PKLILPSSKF MDQTKQPCHT LEAVKLMEHE 240
  241 MKHVLVGLTK DLFGPRIKYR WVDTYFPFTQ PSWELEIYFK DNWLEVLGCG IMRHEILQRS 300
  301 GVHQSIGYAF GVGLERLAMV LFDIPDIRLF WS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1b70A
Description: Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phenylalanine-tRNA ligase activity 13.8919118344182 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 12.5698315343202 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 12.5698315343202 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 12.5592545638101 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
glycine-tRNA ligase activity 2.61548498770105 bayes_pls_golite062009
serine-tRNA ligase activity 2.46505535069103 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
binding 0.966824335333342 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
RNA binding 0.524959231698733 bayes_pls_golite062009
transcription regulator activity 0.375542987753806 bayes_pls_golite062009
nucleic acid binding 0.281662799812287 bayes_pls_golite062009
protein binding 0.0804954454681041 bayes_pls_golite062009
DNA binding 0.0309732052586011 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [333-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSGFLSQFS EKDLHNLPKY KPISHYPQCT NDLSFWLPQD IEVDAGFSPN DFYDLVRSVA  60
   61 GDMVEQISLV DKFKHPKTGK SSVCFRIVYR HMERTLTQAE VNEIHKQIAS ASVDSFNVQI 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.98
Match: 1b70B
Description: Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

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