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Protein Overview: arr-PA

General Information:
Name(s) found: arr-PA / FBpp0086821 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene arrow is referred to in FlyBase by the symbol Dmel\arr (CG5912, FBgn0000119). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9341138..9370723. It has the cytological map location 50A9-50A11. There is experimental evidence that it has the molecular function</span>: Wnt receptor activity; protein binding. There is experimental evidence that it is involved in the biological process</span>: nervous system development; regulation of compound eye pigmentation; Wnt receptor signaling pathway; protein targeting to lysosome; compound eye morphogenesis. 38 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; cuticle; nervous system; peripheral nervous system; embryonic nervous system; integumentary system; cuticular specialization; external compound sense organ; midgut constriction; acellular anatomical structure; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1678 amino acids

    Gene Ontology:
    Cellular Component: early endosome [IDA]
    late endosome [IDA]
    plasma membrane [IDA]
    Biological Process: regulation of compound eye pigmentation [IMP]
    compound eye morphogenesis [IMP]
    nervous system development [IMP]
    Wnt receptor signaling pathway [IMP]
    protein targeting to lysosome [IMP]
    Molecular Function: Wnt receptor activity [IDA]
    protein binding [IDA]
    low-density lipoprotein receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEPYTKSA EIEPQLCQVI DNNEDVTTKA TKCTKSNSGV GWRQMLIGFL LICFGISNSW  60
   61 QYKNVHMPSS SSLIASPPAS AFVNTPATLL FTTRHDIQVA NITRPTGGPQ IDVIVRDLAE 120
  121 AMAIDFYYAK NLVCWTDSGR EIIECAQTNS SALQPLLRAP KQTVISTGLD KPEGLAMDWY 180
  181 TDKIYWTDGE KNRIEVATLD GRYQKVLFWT DLDQPRAVAV VPARKLLIWT DWGEYPKIER 240
  241 ASMDGDPLSR MTLVKEHVFW PNGLAVDLKN ELIYWTDGKH HFIDVMRLDG SSRRTIVNNL 300
  301 KYPFSLTFYD DRLYWTDWQR GSLNALDLQT RELKELIDTP KAPNSVRAWD PSLQPYEDNP 360
  361 CAHNNGNCSH LCLLATNSQG FSCACPTGVK LISANTCANG SQEMMFIVQR TQISKISLDS 420
  421 PDYTIFPLPL GKVKYAIAID YDPVEEHIYW SDVETYTIKR AHADGTGVTD FVTSEVRHPD 480
  481 GLALDWLARN LYWTDTVTDR IEVCRLDGTA RKVLIYEHLE EPRAIAVAPS LGWMFWSDWN 540
  541 ERKPKVERAS LDGSERVVLV SENLGWPNGI ALDIEAKAIY WCDGKTDKIE VANMDGSGRR 600
  601 VVISDNLKHL FGLSILDDYL YWTDWQRRSI DRAHKITGNN RIVVVDQYPD LMGLKVTRLR 660
  661 EVRGQNACAV RNGGCSHLCL NRPRDYVCRC AIDYELANDK RTCVVPAAFL LFSRQEHIGR 720
  721 ISIEYNEGNH NDERIPFKDV RDAHALDVSV AERRIYWTDQ KSKCIFRAFL NGSYVQRIVD 780
  781 SGLIGPDGIA VDWLANNIYW SDAEARRIEV ARLDGSSRRV LLWKGVEEPR SLVLEPRRGY 840
  841 MYWTESPTDS IRRAAMDGSD LQTIVAGANH AAGLTFDQET RRLYWATQSR PAKIESADWD 900
  901 GKKRQILVGS DMDEPYAVSL YQDYVYWSDW NTGDIERVHK TTGQNRSLVH SGMTYITSLL 960
  961 VFNDKRQTGV NPCKVNNGGC SHLCLAQPGR RGMTCACPTH YQLAKDGVSC IPPRNYIIFS1020
 1021 QRNCFGRLLP NTTDCPNIPL PVSGKNIRAV DYDPITHHIY WIEGRSHSIK RSLANGTKVS1080
 1081 LLANSGQPFD LAIDIIGRLL FWTCSQSNSI NVTSFLGESV GVIDTGDSEK PRNIAVHAMK1140
 1141 RLLFWTDVGS HQAIIRARVD GNERVELAYK LEGVTALALD QQSDMIYYAH GKRIDAIDIN1200
 1201 GKNKKTLVSM HISQVINIAA LGGFVYWLDD KTGVERITVN GERRSAELQR LPQITDIRAV1260
 1261 WTPDPKVLRN HTCMHSRTKC SHICIASGEG IARTRDVCSC PKHLMLLEDK ENCGAFPACG1320
 1321 PDHFTCAAPV SGISDVNKDC IPASWRCDGQ KDCPDKSDEV GCPTCRADQF SCQSGECIDK1380
 1381 SLVCDGTTNC ANGHDEADCC KRPGEFQCPI NKLCISAALL CDGWENCADG ADESSDICLQ1440
 1441 RRMAPATDKR AFMILIGATM ITIFSIVYLL QFCRTRIGKS RTEPKDDQAT DPLSPSTLSK1500
 1501 SQRVSKIASV ADAVRMSTLN SRNSMNSYDR NHITGASSST TNGSSMVAYP INPPPSPATR1560
 1561 SRRPYRHYKI INQPPPPTPC STDICDESDS NYTSKSNSNN SNGGATKHSS SSAAACLQYG1620
 1621 YDSEPYPPPP TPRSHYHSDV RIVPESSCPP SPSSRSSTYF SPLPPPPSPV QSPSRGFT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..418] PSI-BLAST 93.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    2 View Details [419..664] PSI-BLAST 75.0 Crystal structure of Nidogen/Laminin Complex
    3 View Details [665..756] FFAS03 4.79 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    4 View Details [757..1250] FFAS03 3.93 No description for 2z2nA was found.
    5 View Details [1251..1290] PSI-BLAST 5.0 No description for 2dtgE was found.
    6 View Details [1291..1678] PSI-BLAST 5.522879 Strucuture of the C-terminal domain of human thrombospondin-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor activity
    		•  5.18957329214193 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.12821337870369 bayes_pls_golite062009
  • growth factor activity
    		•  4.72461268561406 bayes_pls_golite062009
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • protein binding
    		•  3.02592228806142 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.88127286867262 bayes_pls_golite062009
  • heparin binding
    		•  2.73820379449342 bayes_pls_golite062009
  • binding
    		•  2.54996368217395 bayes_pls_golite062009
  • lipoprotein binding
    		•  2.49586534030898 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.197145317433 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.04860930279383 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  1.76602889313095 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.52943230565474 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.45792086043869 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • pattern binding
    		•  1.40261567769805 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • transcription factor binding
    		•  1.35328446721926 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  1.33530873314599 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.08803800589535 bayes_pls_golite062009
  • Wnt receptor activity
    		•  0.91033392909889 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.724489340907325 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.6530199085873 bayes_pls_golite062009
  • apolipoprotein binding
    		•  0.598690562495919 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.50737750327034 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.128291636237359 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0566254663933097 bayes_pls_golite062009
    2
    Term Confidence Notes
  • receptor activity
    		•  5.18957329214193 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.12821337870369 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.28859337937742 bayes_pls_golite062009
  • signal transducer activity
    		•  4.28859337937742 bayes_pls_golite062009
  • protein binding
    		•  3.16714127217673 bayes_pls_golite062009
  • binding
    		•  2.67985823019393 bayes_pls_golite062009
  • growth factor activity
    		•  2.52088398765308 bayes_pls_golite062009
  • lipoprotein binding
    		•  2.49586534030898 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  1.76602889313095 bayes_pls_golite062009
  • receptor binding
    		•  1.72672102029619 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  1.33530873314599 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.08803800589535 bayes_pls_golite062009
  • Wnt receptor activity
    		•  0.91033392909889 bayes_pls_golite062009
  • apolipoprotein binding
    		•  0.598690562495919 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0566254663933097 bayes_pls_golite062009
    3
    Term Confidence Notes
  • growth factor activity
    		•  4.33479937975628 bayes_pls_golite062009
  • receptor binding
    		•  3.99541876330624 bayes_pls_golite062009
  • protein binding
    		•  2.87649191391668 bayes_pls_golite062009
  • heparin binding
    		•  2.45922265758085 bayes_pls_golite062009
  • binding
    		•  2.4527651483634 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.28286857040435 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.79528213050973 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66370136016696 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66370136016696 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.62745846687818 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.29534342979498 bayes_pls_golite062009
  • pattern binding
    		•  1.18858604250595 bayes_pls_golite062009
  • transcription factor binding
    		•  1.12709437655272 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.938743965687308 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.654704378168009 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.522998725269686 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.346221179082765 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.237963823897778 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.221914592276874 bayes_pls_golite062009
  • catalytic activity
    		•  0.0197550253779933 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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