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Protein Overview: fra-PA

General Information:
Name(s) found: fra-PA / FBpp0086935 [FlyBase]
Description(s) found:
Found 20 descriptions.
SHOW ALL
  • The gene frazzled is referred to in FlyBase by the symbol Dmel\fra (CG8581, FBgn0011592). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8416561..8451691. It has the cytological map location 49A10-49B3. It is reported to have molecular function</span>: netrin receptor activity. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; axon guidance; axon midline choice point recognition; dendrite guidance. 23 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: multi-cell-component structure; embryonic nervous system; nervous system; commissure; organ system; embryonic neuron; peripheral nervous system; supraesophageal ganglion neuron; adult segment; larval head nerve; embryonic foregut. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1526 amino acids

    Gene Ontology:
    Cellular Component: dendrite [IDA]
    integral to membrane [IEA]
    neuronal cell body [IDA]
    plasma membrane [ISS]
    axon [IDA]
    Biological Process: motor axon guidance [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [IMP][NAS][TAS]
    axon midline choice point recognition [IMP]
    dendrite guidance [IMP]
    dendrite morphogenesis [TAS]
    Molecular Function: netrin receptor activity [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAITTNRSSR TLWNWLLSSC LIFQLIGSSL ASQALSFTLE PQDAVVPEGH SVLLQCAGTA  60
   61 SIGRGGKSKS NLPSSVSIRW RGPDGQDLVI VGDTFRTQLK NGSLYISSVE ENRGLTGAYQ 120
  121 CLLTAEGVGS ILSRPALVAI VRQPDLNQDF LETYLLPGQT AYFRCMLGEA NWQEGVKHSV 180
  181 QWLKDDLPLP LDKLRMVVLP NGALEIDEVG PSDRGSYQCN VTSGSSSRLS SKTNLNIKKP 240
  241 SDPGAENSVA PSFLVGPSPK TVREGDTVTL DCVANGVPKP QIKWLRNGMD LDFNDLDSRF 300
  301 SIVGTGSLQI SSAEDIDSGN YQCRASNTVD SLDAQATVQV QEPPKFIKAP KDTTAHEKDE 360
  361 PELKCDIWGK PKPVIRWLKN GDLITPNDYM QLVDGHNLKI LGLLNSDAGM FQCVGTNAAG 420
  421 SVHAAARLRV VPQGVKIKKR KSQGHSTKSL QTFDNLTKRR KPFNSGEQLR TKSGGSFPFP 480
  481 DEDDDLDDND SGTTRLRIPS GKLPKFEQPL NDRRFNILNA GSALPLDNQS KSYEDDDDDY 540
  541 DEDDPAKEAL LEAYKQGEDA HKILDSWQQS KSKKSQQQKQ SPASPDSPEQ DPSVPHPGGK 600
  601 PLDSGLQARL PSQPRDLVAQ IVKSRFVTLS WVEPLQNAGD VVYYTVYYKM NNSEREQKMV 660
  661 TKSHDDQQVN IQSLLPGRTY QFRVEANTNF GSGASSAPLE VSTQPEVNIA GPPRNFEGYA 720
  721 RSHKEIYVKW EEPTVTNGEI LKYRVYYSEN DSGADLYHDS TALEAVLTEL RPHTDYVISV 780
  781 VPFNRNGMGD SSAEIRVKTF SSTPSEPPNN VTLEVTSSSS ITVHWEPPAE EDRNGQITGY 840
  841 KIRYRKFKDA PQVKSTPANI RYFELSNLDR NAEYQVKIAA MTVNGSGPFT EWNRANTLEN 900
  901 DLDETQVPGK PIWISIHPGA NNIALHWGPP QHPEIKIRNY VLGWGRGIPD ENTIELKETE 960
  961 RYHILKNLES NMDYVVSLRA RNVKGDGPPI YDNIKTRDEE PVDAPTPLEV PVGLRAITMS1020
 1021 SSSIVVYWID TMLNKNQHVT DNRHYTVSYG ITGSNRYRYH NTTDLNCMIN DLRPNTQYEF1080
 1081 AVKVVKGRRE SSWSMSVLNS TYQNVPVTPP REVTVRLDEM NPPTVIVQWI PPKHTLGQIT1140
 1141 GYNIYYTTDT TKRDRDWSVE AFAGEETMLM LPNLKPYTTY YFKVQARTTK GANNAPFSAL1200
 1201 VSYTTSAAVT MQEPDTIAKG IDNEKLLYII IAATAVVLLV VLLGVLLLCR RKPQSSPEHT1260
 1261 KKSYQKNNVG VPKPPDLWIH HDQMELKNID KGLHTVTPVC SDGASSSGAL TLPRSVVHSE1320
 1321 YEVETPVPGH VTNSLDKRSY VPGYMTTSMN GTMERPQYPR TQYSHQNRSH MTMEAGLSQQ1380
 1381 SLTQPQSNSM AQTPEHPYGG YDANFCNAGN AAAGNGCVST IESSKRGHPL KSFSVPGPPP1440
 1441 TGGATPVTKH TPAVTIRPQN QSPYKKPSFS AATPNRLQGG GSVVHSTDEI QRLAPSTSTE1500
 1501 ELNQEMANLE GLMKDLSAIT ANEFEC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] PSI-BLAST 62.39794 Axonin-1
    2 View Details [129..611] PSI-BLAST 8.39794 No description for 2ec8A was found.
    3 View Details [612..707] PSI-BLAST 10.09691 The solution structure of the first fibronectin type III domain of human Neogenin
    4 View Details [708..803] PSI-BLAST 14.221849 The solution structure of the second fibronectin type III domain of human Neogenin
    5 View Details [804..909] PSI-BLAST 18.30103 The solution structure of the third fibronectin type III domain of human Neogenin
    6 View Details [910..997] PSI-BLAST 14.69897 The solution structure of the fourth fibronectin type III domain of human Neogenin
    7 View Details [998..1102] PSI-BLAST 7.69897 The solution structure of the fifth fibronectin type III domain of human Neogenin
    8 View Details [1103..1205] PSI-BLAST 15.30103 The solution structure of the sixth fibronectin type III domain of human Neogenin
    9 View Details [1206..1350] PSI-BLAST 7.0 Solution structure of the fourth fn3 domain of KIAA1496 protein
    10 View Details [1351..1526] MSA 1.18999 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    4
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    5
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    6
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    7
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    8
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    9
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • binding
    		•  2.33694299384015 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • signal transducer activity
    		•  2.21983239105819 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.59127031206947 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.36779576054347 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.35537832915522 bayes_pls_golite062009
  • kinase activity
    		•  1.27518127128831 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.870650302384902 bayes_pls_golite062009
  • receptor binding
    		•  0.68707729411717 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.578947214531819 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.41697290440207 bayes_pls_golite062009
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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