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View Structure Prediction Details

Protein: fra-PA
Organism: Drosophila melanogaster
Length: 1526 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fra-PA.

Description E-value Query
Range		 Subject
Range
gi|1621117, gi|7... - pir||T13823 frazzled gene protein, log isoform - fruit fly (Drosophila melanogaster), gi|1621117|gb...
 899.0 [0..19] [1526..19]

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Predicted Domain #1
Region A:
Residues: [1-128] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAITTNRSSR TLWNWLLSSC LIFQLIGSSL ASQALSFTLE PQDAVVPEGH SVLLQCAGTA  60
   61 SIGRGGKSKS NLPSSVSIRW RGPDGQDLVI VGDTFRTQLK NGSLYISSVE ENRGLTGAYQ 120
  121 CLLTAEGV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.39794
Match: 1cs6A
Description: Axonin-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [129-611] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSILSRPALV AIVRQPDLNQ DFLETYLLPG QTAYFRCMLG EANWQEGVKH SVQWLKDDLP  60
   61 LPLDKLRMVV LPNGALEIDE VGPSDRGSYQ CNVTSGSSSR LSSKTNLNIK KPSDPGAENS 120
  121 VAPSFLVGPS PKTVREGDTV TLDCVANGVP KPQIKWLRNG MDLDFNDLDS RFSIVGTGSL 180
  181 QISSAEDIDS GNYQCRASNT VDSLDAQATV QVQEPPKFIK APKDTTAHEK DEPELKCDIW 240
  241 GKPKPVIRWL KNGDLITPND YMQLVDGHNL KILGLLNSDA GMFQCVGTNA AGSVHAAARL 300
  301 RVVPQGVKIK KRKSQGHSTK SLQTFDNLTK RRKPFNSGEQ LRTKSGGSFP FPDEDDDLDD 360
  361 NDSGTTRLRI PSGKLPKFEQ PLNDRRFNIL NAGSALPLDN QSKSYEDDDD DYDEDDPAKE 420
  421 ALLEAYKQGE DAHKILDSWQ QSKSKKSQQQ KQSPASPDSP EQDPSVPHPG GKPLDSGLQA 480
  481 RLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.39794
Match: 2ec8A
Description: No description for 2ec8A was found.

Predicted Domain #3
Region A:
Residues: [612-707] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQPRDLVAQI VKSRFVTLSW VEPLQNAGDV VYYTVYYKMN NSEREQKMVT KSHDDQQVNI  60
   61 QSLLPGRTYQ FRVEANTNFG SGASSAPLEV STQPEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.09691
Match: 1x5fA
Description: The solution structure of the first fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [708-803] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIAGPPRNFE GYARSHKEIY VKWEEPTVTN GEILKYRVYY SENDSGADLY HDSTALEAVL  60
   61 TELRPHTDYV ISVVPFNRNG MGDSSAEIRV KTFSST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.221849
Match: 1x5gA
Description: The solution structure of the second fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [804-909] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSEPPNNVTL EVTSSSSITV HWEPPAEEDR NGQITGYKIR YRKFKDAPQV KSTPANIRYF  60
   61 ELSNLDRNAE YQVKIAAMTV NGSGPFTEWN RANTLENDLD ETQVPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 1x5hA
Description: The solution structure of the third fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [910-997] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPIWISIHPG ANNIALHWGP PQHPEIKIRN YVLGWGRGIP DENTIELKET ERYHILKNLE  60
   61 SNMDYVVSLR ARNVKGDGPP IYDNIKTR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1x5iA
Description: The solution structure of the fourth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [998-1102] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEPVDAPTP LEVPVGLRAI TMSSSSIVVY WIDTMLNKNQ HVTDNRHYTV SYGITGSNRY  60
   61 RYHNTTDLNC MINDLRPNTQ YEFAVKVVKG RRESSWSMSV LNSTY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1x5jA
Description: The solution structure of the fifth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1103-1205] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNVPVTPPRE VTVRLDEMNP PTVIVQWIPP KHTLGQITGY NIYYTTDTTK RDRDWSVEAF  60
   61 AGEETMLMLP NLKPYTTYYF KVQARTTKGA NNAPFSALVS YTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 1x5kA
Description: The solution structure of the sixth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1206-1350] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAVTMQEPD TIAKGIDNEK LLYIIIAATA VVLLVVLLGV LLLCRRKPQS SPEHTKKSYQ  60
   61 KNNVGVPKPP DLWIHHDQME LKNIDKGLHT VTPVCSDGAS SSGALTLPRS VVHSEYEVET 120
  121 PVPGHVTNSL DKRSYVPGYM TTSMN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1wj3A
Description: Solution structure of the fourth fn3 domain of KIAA1496 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
binding 2.33694299384015 bayes_pls_golite062009
molecular transducer activity 2.21983239105819 bayes_pls_golite062009
signal transducer activity 2.21983239105819 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
axon guidance receptor activity 1.64934167161651 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
cell adhesion molecule binding 1.59127031206947 bayes_pls_golite062009
cytokine receptor activity 1.36779576054347 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.35537832915522 bayes_pls_golite062009
kinase activity 1.27518127128831 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.870650302384902 bayes_pls_golite062009
receptor binding 0.68707729411717 bayes_pls_golite062009
protein serine/threonine kinase activity 0.578947214531819 bayes_pls_golite062009
transferase activity 0.432850266451294 bayes_pls_golite062009
peptide hormone binding 0.41697290440207 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1351-1526] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTMERPQYPR TQYSHQNRSH MTMEAGLSQQ SLTQPQSNSM AQTPEHPYGG YDANFCNAGN  60
   61 AAAGNGCVST IESSKRGHPL KSFSVPGPPP TGGATPVTKH TPAVTIRPQN QSPYKKPSFS 120
  121 AATPNRLQGG GSVVHSTDEI QRLAPSTSTE ELNQEMANLE GLMKDLSAIT ANEFEC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle