Protein Overview: Prp8-PA

General Information:
Name(s) found:	Prp8-PA / FBpp0087124 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7303518\|gb\|AAF58573.1\| prp8 [Drosophila melanogaster] [NCBI NR] gi\|20129897\|ref\|NP_610735.1\| prp8 [Drosophila melanogaster] [NCBI NR] The gene pre-mRNA processing factor 8 is referred to in FlyBase by the symbol Dmel\Prp8 (CG8877, FBgn0033688). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8041763..8050496. It has the cytological map location 48E3-48E4. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: nuclear mRNA splicing, via spliceosome. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG8877-PA translation from_gene[CG8877 CG8877 FBgn0033688] seq_release:3 mol_weight=279581 cds_boundaries:(2R:7,219,093..7,227,406[-]) aa_length:2396 transcript_info:[CG8877-RA seq_release:3] gene_info:[gene symbol:CG8877 FBgn0033688 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q9V664) CG8877 protein [DrosMelano7227.FASTAC.txt] (AE003823) CG8877 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG8877-PA [Drosophila melanogaster]gi\|20129897\|ref\|NP_610735.1\| CG8877-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:complement(8041882..8044826,8044890..8045181,8045260..8045436,8045498..8045648,8045715..8046288,8046512..8046704,8046767..8047818,8047876..8048093,8048152..8048571,8048852..8048977,8049040..8049252,8049313..8049528,8049585..8050198); [fly-100309-contam.fasta] CG8877-PA [Drosophila melanogaster] [nr-271106-contam.fasta] prp8 CG8877-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(8041882..8044826,8044890..8045181,8045260..8045436,8045498..8045648,8045715..8046288,8046512..8046704,8046767..8047818,8047876..8048093,8048152..8048571,8048852..8048977,8049040..8049252,8049313..8049528,8049585..8050198); ID=FBpp0087124; name=prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(8041882..8044826,8044890..8045181,8045260..8045436,8045498..8045648,8045715..8046288,8046512..8046704,8046767..8047818,8047876..8048093,8048152..8048571,8048852..8048977,8049040..8049252,8049313..8049528,8049585..8050198); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Pre-mRNA processing factor 8 OS=Drosophila melanogaster GN=Prp8 PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:complement(8041882..8044826,8044890..8045181,8045260..8045436,8045498..8045648,8045715..8046288,8046512..8046704,8046767..8047818,8047876..8048093,8048152..8048571,8048852..8048977,8049040..8049252,8049313..8049528,8049585..8050198); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573,FlyMine:FBpp0087124,modMine:FBpp0087124; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] pre-mRNA processing factor 8 [Drosophila melanogaster] [2012-10-yates-His-Tub4-plus-reversed.fasta] type=protein; loc=2R:complement(join(12162080..12162693,12161808..12162023,12161535..12161747,12161347..12161472,12160647..12161066,12160371..12160588,12159262..12160313,12159007..12159199,12158210..12158783,12157993..12158143,12157755..12157931,12157385..12157676,12154377..12157321)); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573,FlyMine:FBpp0087124,modMine:FBpp0087124; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(12162080..12162693,12161808..12162023,12161535..12161747,12161347..12161472,12160647..12161066,12160371..12160588,12159262..12160313,12159007..12159199,12158210..12158783,12157993..12158143,12157755..12157931,12157385..12157676,12154377..12157321)); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573,FlyMine:FBpp0087124,modMine:FBpp0087124; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Pre-mRNA processing factor 8 OS=Drosophila melanogaster GN=Prp8 PE=1 SV=1 [DROME.fasta.20160308] FBpp0087124 type=protein; loc=2R:complement(join(12162080..12162693,12161808..12162023,12161535..12161747,12161347..12161472,12160647..12161066,12160371..12160588,12159262..12160313,12159007..12159199,12158210..12158783,12157993..12158143,12157755..12157931,12157385..12157676,12154377..12157321)); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573,FlyMine:FBpp0087124,modMine:FBpp0087124; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(12162080..12162693,12161808..12162023,12161535..12161747,12161347..12161472,12160647..12161066,12160371..12160588,12159262..12160313,12159007..12159199,12158210..12158783,12157993..12158143,12157755..12157931,12157385..12157676,12154377..12157321)); ID=FBpp0087124; name=Prp8-PA; parent=FBgn0033688,FBtr0088016; dbxref=FlyBase:FBpp0087124,FlyBase_Annotation_IDs:CG8877-PA,GB_protein:AAF58573.1,REFSEQ:NP_610735,GB_protein:AAF58573,UniProt/TrEMBL:A1Z8U0,FlyMine:FBpp0087124,modMine:FBpp0087124; MD5=2126edc39c297a41431d0a901d104bd6; length=2396; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2396 amino acids
Gene Ontology:
Cellular Component:	U5 snRNP [ISS] spliceosomal complex [ISS]
Biological Process:	nuclear mRNA splicing, via spliceosome [IMP][ISS]
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPPYMIPQ NAWAAQLMAQ QAYAAAHAQQ AQLHAQQQMA NQIQQIPPPG APLPPAGGHT  60
   61 NGIPIPVGGQ GPGLGQIPTP KPDILTEEKL QEKALKWQHL QSKRFAEKRK FGFVDTQKED 120
  121 MPPEHIRKII RDHGDMTSRK YRHDKRVYLG ALKYMPHAVL KLLENMPMPW EQIRDVQVLY 180
  181 HITGAITFVN EIPWVIEPVY IAQWGTMWIM MRREKRDRRH FKRMRFPPFD DEEPPLDYAD 240
  241 NVLDVEPLEA IQIELDNDED NAVYKWFYDH RPLVDTQFVN GTTYRKWNLS LPQLATLYRL 300
  301 ANQLLTDLVD NNFFYLFDPK SFFTAKALNM AIPGGPKFEP LIKDHNVGDE DWNEFNDINK 360
  361 VIIRQPIRTE YRIAFPYLYN NMPHFVHLSW YHTPNVVYIK TEDPDLPAFY FDPLINPISH 420
  421 RNANSKIQEP LPDDDEDFTL PDDVQPFLQD TPLYTDNTAN GIALLWAPRP FNMRSGRSRR 480
  481 AIDVPLVKCW YKEHCPPGHP VKVRVSYQKL LKYYVLNALK HRKPKPQKKR YLFRSFKATK 540
  541 FFQTTTLDWV EAGLQVCRQG YNMLNLLIHR KNLNYLHLDY NFNLKPVKTL TTKERKKSRF 600
  601 GNAFHLCREI LRLTKLIIDS HVQYRLNNVD AFQLADGLQY IFAHVGQLTG MYRYKYKLMR 660
  661 QIRMCKDLKH LIYYRFNTGP VGKGPGCGFW APGWRVWLFF MRGITPLLER WLGNLLSRQF 720
  721 EGRHSKGVAK TVTKQRVESH FDLELRASVM HDIVDMMPEG IKQNKARTIL QHLSEAWRCW 780
  781 KANIPWKVPG LPIPIENMIL RYVKMKADWW TNTAHYNRER IRRGATVDKT VCKKNLGRLT 840
  841 RLYLKAEQER QHNYLKDGPY ISPEEAVAIY TTTVHWLESR RFAPIPFPPL SYKHDTKLLI 900
  901 LALERLKEAY SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQRA FKEVGIEFMD 960
  961 LYSHLIPVYE VEPLEKITDA YLDQYLWYEA DKRRLFPPWI KPSDTEPPPL LAYKWCQGIN1020
 1021 NLQDVWDVGE GECNVLLESR FEKLYEKIDL TLLNRLLRLI VDHNIADYMT AKNNVVINYK1080
 1081 DMNHTNSYGI IRGLQFSSFI TQYYGLVLDL LVLGLHRSSE MAGPPQMPND FLTFQDTVTE1140
 1141 TAHPIRLYCR YVDRIHLFFR FSAEEARDLI QRYLTEHPDP NNENIVGYNN KKCWPRDARM1200
 1201 RLMKHDVNLG RAVFWDIKNR LPRSVTTIGW ESTFVSVYSK DNPNLLFNMS GFECRILPKC1260
 1261 RTQNEEFTHR DGVWNLQNEI TKERTAQCFL RVDDESLGRF HNRVRQILMA SGSTTFTKIV1320
 1321 NKWNTALIGL MTYFREAVVN TQELLDLLVK CENKIQTRIK IGLNSKMPSR FPPVVFYTPK1380
 1381 ELGGLGMLSM GHVLIPQSDL RWSKQTDVGI THFRSGMSHD EDQLIPNLYR YIQPWESEFI1440
 1441 DSQRVWAEYA LKRQEANAQN RRLTLEDLED SWDRGIPRIN TLFQKDRHTL AYDKGWRIRT1500
 1501 EFKQYQVLKQ NPFWWTHQRH DGKLWNLNNY RTDMIQALGG VEGILEHTLF KGTYFPTWEG1560
 1561 LFWEKASGFE ESMKYKKLTN AQRSGLNQIP NRRFTLWWSP TINRANVYVG FQVQLDLTGI1620
 1621 FMHGKIPTLK ISLIQIFRAH LWQKIHESIV MDLCQVFDQE LDALEIETVQ KETIHPRKSY1680
 1681 KMNSSCADIL LFPAYKWNVS RPSLLADTKD TMDNTTTQKY WLDIQLRWGD YDSHDVERYA1740
 1741 RAKFLDYTTD NMSIYPSPTG VLIAIDLAYN LHSAYGNWFP GCKTLIQQAM AKIMKANPAL1800
 1801 YVLRERIRKA LQLYSSEPTE PYLSSQNYGE LFSNQIIWFV DDTNVYRVTI HKTFEGNLTT1860
 1861 KPINGAIFIF NPRTGQLFLK IIHTSVWAGQ KRLGQLAKWK TAEEVAALIR SLPVEEQPKQ1920
 1921 IIVTRKGMLD PLEVHLLDFP NIVIKGSELQ LPFQACLKVE KFGDLILKAT EPQMVLFNLY1980
 1981 DDWLKTISSY TAFSRLILIL RALHVNTERT KIILKPDKTT ITEAHHIWPT LTDEEWIKVE2040
 2041 VQLKDLILAD YGKKNNVNVA SLTQSEIRDI ILGMEISAPS AQRQQIAEIE KQTKEQNQLT2100
 2101 ATTTRTTNKH GDEIITSTTS NYETQTFSSK TEWRVRAISA TNLHLRTNHI YVSSDDIKET2160
 2161 GYTYILPKNI LKKFVTISDL RAQIAGYLYG VSPPDNPQVK EIRCIVMPPQ WGTHQTINLP2220
 2221 NTLPTHQYLK DMEPLGWIHT QPNELPQLSP QDITTHAKIM QENSNWDGEK TIVITCSFTP2280
 2281 GSCSLTAYKL TPSGFEWGSK NTDKGNNPKG YLPSHYERVQ MLLSNKFLGF FMVPAQSSWN2340
 2341 YNFMGVRHDP NMKYELQLAN PKEFYHELHR TSHFLLFSNL EDGGDGAGAD REDVYA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..112]	MSA	1.025981	View MSA. No confident structure predictions are available.
2	View Details	[113..273]	Pfam	123.346787	No description for PF08082.2 was found. No confident structure predictions are available.
3	View Details	[274..346]	deduced	N/A	No confident structure predictions are available.
4	View Details	[347..525]	MSA	1.032961	View MSA. No confident structure predictions are available.
5	View Details	[526..593]	deduced	N/A	No confident structure predictions are available.
6	View Details	[594..684]	MSA	1.034953	View MSA. No confident structure predictions are available.
7	View Details	[685..787]	deduced	N/A	No confident structure predictions are available.
8	View Details	[788..890]	deduced	N/A	No confident structure predictions are available.
9	View Details	[891..1067]	deduced	N/A	No confident structure predictions are available.
10	View Details	[1068..1204]	deduced	N/A	No confident structure predictions are available.
11	View Details	[1205..1318]	MSA	1.038944	View MSA. No confident structure predictions are available.
12	View Details	[1319..1507]	deduced	N/A	No confident structure predictions are available.
13	View Details	[1508..1567]	MSA	4.04399	View MSA. No confident structure predictions are available.
14	View Details	[1568..1796]	deduced	N/A	No confident structure predictions are available.
15	View Details	[1797..1986]	MSA	1.035951	View MSA. No confident structure predictions are available.
16	View Details	[1987..2055]	deduced	N/A	No confident structure predictions are available.
17	View Details	[2056..2098]	MSA	1.045992	View MSA. No confident structure predictions are available.
18	View Details	[2099..2396]	PSI-BLAST	112.0	No description for 2p87A was found.

Protein Overview: Prp8-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: