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View Structure Prediction Details

Protein: Prp8-PA
Organism: Drosophila melanogaster
Length: 2396 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prp8-PA.

Description E-value Query
Range
Subject
Range
gi|76643613 - gi|76643613|ref|XP_888305.1| PREDICTED: similar to Pre-mRNA processing splicing factor 8 (Splicing f...
4674.0 [0..60] [2396..1]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPPYMIPQ NAWAAQLMAQ QAYAAAHAQQ AQLHAQQQMA NQIQQIPPPG APLPPAGGHT  60
   61 NGIPIPVGGQ GPGLGQIPTP KPDILTEEKL QEKALKWQHL QSKRFAEKRK FG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [113-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVDTQKEDMP PEHIRKIIRD HGDMTSRKYR HDKRVYLGAL KYMPHAVLKL LENMPMPWEQ  60
   61 IRDVQVLYHI TGAITFVNEI PWVIEPVYIA QWGTMWIMMR REKRDRRHFK RMRFPPFDDE 120
  121 EPPLDYADNV LDVEPLEAIQ IELDNDEDNA VYKWFYDHRP L

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 123.346787
Match: PF08082.2
Description: No description for PF08082.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [274-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDTQFVNGTT YRKWNLSLPQ LATLYRLANQ LLTDLVDNNF FYLFDPKSFF TAKALNMAIP  60
   61 GGPKFEPLIK DHN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [347-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGDEDWNEFN DINKVIIRQP IRTEYRIAFP YLYNNMPHFV HLSWYHTPNV VYIKTEDPDL  60
   61 PAFYFDPLIN PISHRNANSK IQEPLPDDDE DFTLPDDVQP FLQDTPLYTD NTANGIALLW 120
  121 APRPFNMRSG RSRRAIDVPL VKCWYKEHCP PGHPVKVRVS YQKLLKYYVL NALKHRKPK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [526-593]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQKKRYLFRS FKATKFFQTT TLDWVEAGLQ VCRQGYNMLN LLIHRKNLNY LHLDYNFNLK  60
   61 PVKTLTTK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [594-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERKKSRFGNA FHLCREILRL TKLIIDSHVQ YRLNNVDAFQ LADGLQYIFA HVGQLTGMYR  60
   61 YKYKLMRQIR MCKDLKHLIY YRFNTGPVGK G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [685-787]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGCGFWAPGW RVWLFFMRGI TPLLERWLGN LLSRQFEGRH SKGVAKTVTK QRVESHFDLE  60
   61 LRASVMHDIV DMMPEGIKQN KARTILQHLS EAWRCWKANI PWK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [788-890]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGLPIPIEN MILRYVKMKA DWWTNTAHYN RERIRRGATV DKTVCKKNLG RLTRLYLKAE  60
   61 QERQHNYLKD GPYISPEEAV AIYTTTVHWL ESRRFAPIPF PPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [891-1067]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYKHDTKLLI LALERLKEAY SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQRA  60
   61 FKEVGIEFMD LYSHLIPVYE VEPLEKITDA YLDQYLWYEA DKRRLFPPWI KPSDTEPPPL 120
  121 LAYKWCQGIN NLQDVWDVGE GECNVLLESR FEKLYEKIDL TLLNRLLRLI VDHNIAD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1068-1204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YMTAKNNVVI NYKDMNHTNS YGIIRGLQFS SFITQYYGLV LDLLVLGLHR SSEMAGPPQM  60
   61 PNDFLTFQDT VTETAHPIRL YCRYVDRIHL FFRFSAEEAR DLIQRYLTEH PDPNNENIVG 120
  121 YNNKKCWPRD ARMRLMK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1205-1318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDVNLGRAVF WDIKNRLPRS VTTIGWESTF VSVYSKDNPN LLFNMSGFEC RILPKCRTQN  60
   61 EEFTHRDGVW NLQNEITKER TAQCFLRVDD ESLGRFHNRV RQILMASGST TFTK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1319-1507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVNKWNTALI GLMTYFREAV VNTQELLDLL VKCENKIQTR IKIGLNSKMP SRFPPVVFYT  60
   61 PKELGGLGML SMGHVLIPQS DLRWSKQTDV GITHFRSGMS HDEDQLIPNL YRYIQPWESE 120
  121 FIDSQRVWAE YALKRQEANA QNRRLTLEDL EDSWDRGIPR INTLFQKDRH TLAYDKGWRI 180
  181 RTEFKQYQV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [1508-1567]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKQNPFWWTH QRHDGKLWNL NNYRTDMIQA LGGVEGILEH TLFKGTYFPT WEGLFWEKAS  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1568-1796]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFEESMKYKK LTNAQRSGLN QIPNRRFTLW WSPTINRANV YVGFQVQLDL TGIFMHGKIP  60
   61 TLKISLIQIF RAHLWQKIHE SIVMDLCQVF DQELDALEIE TVQKETIHPR KSYKMNSSCA 120
  121 DILLFPAYKW NVSRPSLLAD TKDTMDNTTT QKYWLDIQLR WGDYDSHDVE RYARAKFLDY 180
  181 TTDNMSIYPS PTGVLIAIDL AYNLHSAYGN WFPGCKTLIQ QAMAKIMKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #15
Region A:
Residues: [1797-1986]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPALYVLRER IRKALQLYSS EPTEPYLSSQ NYGELFSNQI IWFVDDTNVY RVTIHKTFEG  60
   61 NLTTKPINGA IFIFNPRTGQ LFLKIIHTSV WAGQKRLGQL AKWKTAEEVA ALIRSLPVEE 120
  121 QPKQIIVTRK GMLDPLEVHL LDFPNIVIKG SELQLPFQAC LKVEKFGDLI LKATEPQMVL 180
  181 FNLYDDWLKT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #16
Region A:
Residues: [1987-2055]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISSYTAFSRL ILILRALHVN TERTKIILKP DKTTITEAHH IWPTLTDEEW IKVEVQLKDL  60
   61 ILADYGKKN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #17
Region A:
Residues: [2056-2098]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVNVASLTQS EIRDIILGME ISAPSAQRQQ IAEIEKQTKE QNQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #18
Region A:
Residues: [2099-2396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTATTTRTTN KHGDEIITST TSNYETQTFS SKTEWRVRAI SATNLHLRTN HIYVSSDDIK  60
   61 ETGYTYILPK NILKKFVTIS DLRAQIAGYL YGVSPPDNPQ VKEIRCIVMP PQWGTHQTIN 120
  121 LPNTLPTHQY LKDMEPLGWI HTQPNELPQL SPQDITTHAK IMQENSNWDG EKTIVITCSF 180
  181 TPGSCSLTAY KLTPSGFEWG SKNTDKGNNP KGYLPSHYER VQMLLSNKFL GFFMVPAQSS 240
  241 WNYNFMGVRH DPNMKYELQL ANPKEFYHEL HRTSHFLLFS NLEDGGDGAG ADREDVYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 2p87A
Description: No description for 2p87A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle