YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: en-PB, en-PA

General Information:
Name(s) found: en-PA / FBpp0087198 [FlyBase]
en-PB / FBpp0087197 [FlyBase]
Description(s) found:
Found 36 descriptions.
SHOW ALL
  • The gene engrailed is referred to in FlyBase by the symbol Dmel\en (CG9015, FBgn0000577). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7411509..7415715. It has the cytological map location 47F17-48A1. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: anterior commissure morphogenesis; neuroblast fate determination; axon guidance; spiracle morphogenesis, open tracheal system; ventral midline development; genital disc development; genital disc anterior/posterior pattern formation. 179 alleles are reported. The phenotypes of these alleles are annotated with 90 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; adult mesothoracic segment; nervous system; embryonic nervous system; abdominal ventral denticle belt; multi-cell-component structure; embryonic neuron; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene engrailed is referred to in FlyBase by the symbol Dmel\en (CG9015, FBgn0000577). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7411509..7415715. It has the cytological map location 47F17-48A1. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: anterior commissure morphogenesis; neuroblast fate determination; axon guidance; spiracle morphogenesis, open tracheal system; ventral midline development; genital disc development; genital disc anterior/posterior pattern formation. 179 alleles are reported. The phenotypes of these alleles are annotated with 90 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; adult mesothoracic segment; nervous system; embryonic nervous system; abdominal ventral denticle belt; multi-cell-component structure; embryonic neuron; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: anterior head segmentation [TAS]
    spiracle morphogenesis, open tracheal system [IMP]
    posterior head segmentation [TAS]
    analia development [TAS]
    posterior compartment specification [TAS]
    neuroblast fate determination [IGI]
    segment polarity determination [NAS][TAS]
    regulation of transcription, DNA-dependent [IEA]
    trunk segmentation [TAS]
    axon guidance [IMP]
    compartment pattern formation [NAS][TAS]
    imaginal disc-derived male genitalia development [TAS]
    imaginal disc-derived female genitalia development [TAS]
    imaginal disc pattern formation [TAS]
    regulation of transcription [IEA]
    anterior/posterior pattern formation, imaginal disc [TAS]
    anterior commissure morphogenesis [IMP]
    wing disc anterior/posterior pattern formation [TAS]
    ventral midline development [IMP]
    anterior/posterior lineage restriction, imaginal disc [TAS]
    central nervous system development [NAS]
    negative regulation of transcription [NAS]
    genital disc anterior/posterior pattern formation [IEP][TAS]
    genital disc development [IMP]
    Molecular Function: transcription factor activity [IEA]
    transcription regulator activity [NAS]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]
    transcription repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEDRCSPQ SAPSPITLQM QHLHHQQQQQ QQQQQQMQHL HQLQQLQQLH QQQLAAGVFH  60
   61 HPAMAFDAAA AAAAAAAAAA AHAHAAALQQ RLSGSGSPAS CSTPASSTPL TIKEEESDSV 120
  121 IGDMSFHNQT HTTNEEEEAE EDDDIDVDVD DTSAGGRLPP PAHQQQSTAK PSLAFSISNI 180
  181 LSDRFGDVQK PGKSMENQAS IFRPFEASRS QTATPSAFTR VDLLEFSRQQ QAAAAAATAA 240
  241 MMLERANFLN CFNPAAYPRI HEEIVQSRLR RSAANAVIPP PMSSKMSDAN PEKSALGSLC 300
  301 KAVSQIGQPA APTMTQPPLS SSASSLASPP PASNASTISS TSSVATSSSS SSSGCSSAAS 360
  361 SLNSSPSSRL GASGSGVNAS SPQPQPIPPP SAVSRDSGME SSDDTRSETG STTTEGGKNE 420
  421 MWPAWVYCTR YSDRPSSGPR YRRPKQPKDK TNDEKRPRTA FSSEQLARLK REFNENRYLT 480
  481 ERRRQQLSSE LGLNEAQIKI WFQNKRAKIK KSTGSKNPLA LQLMAQGLYN HTTVPLTKEE 540
  541 EELEMRMNGQ IP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] MSA 9.195994 View MSA. No confident structure predictions are available.
    2 View Details [260..452] deduced N/A No confident structure predictions are available.
    3 View Details [453..552] PSI-BLAST 26.0 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle