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Protein Overview: Prosbeta5-PA, Pr...

General Information:
Name(s) found: Prosbeta5-PA / FBpp0087320 [FlyBase]
Prosbeta5-PB / FBpp0087319 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene Proteasome Ã?&#142;Ã?²5 subunit is referred to in FlyBase by the symbol Dmel\ProsÃ?&#142;Ã?²5 (CG12323, FBgn0029134). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6707469..6708685. It has the cytological map location 47C1. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: centrosome organization; mitotic spindle elongation; cell proliferation; mitotic spindle organization. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Proteasome Ã?&#142;Ã?²5 subunit is referred to in FlyBase by the symbol Dmel\ProsÃ?&#142;Ã?²5 (CG12323, FBgn0029134). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6707469..6708685. It has the cytological map location 47C1. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: centrosome organization; mitotic spindle elongation; cell proliferation; mitotic spindle organization. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex [ISS]
    Biological Process: cell proliferation [IMP]
    mitotic spindle elongation [IMP]
    centrosome organization [IMP]
    mitotic spindle organization [IMP]
    proteolysis involved in cellular protein catabolic process [IEA]
    Molecular Function: endopeptidase activity [ISS][NAS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALAEICKIS NAPYMRPNAW SSADVEEEQK GLMCNLANPY TLAAPPFENP LHNLNQIQAN  60
   61 GDKTGVKINF DHGTTTLGFK FKGGVLLAVD SRATGGSYIG SQSMKKIVEI NQFMLGTLAG 120
  121 GAADCVYWDR VLSKECRLHE LRNKERISVA AASKIMANIA HEYKGMGLSM GMMLAGYDKR 180
  181 GPGLYYVDSE GSRTPGNLFS VGSGSLYAYG VLDSGYHWDL EDKEAQELGR RAIYHATFRD 240
  241 AYSGGIIRVY HIKEDGWVNI SNTDCMELHY MYQEQLKQQA AK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] PSI-BLAST 53.522879 Proteasome beta subunit (catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  0.982918122186083 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle