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Protein Overview: StIP-PA

General Information:
Name(s) found: StIP-PA / FBpp0087307 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene StIP is referred to in FlyBase by the symbol Dmel\StIP (CG11887, FBgn0033540). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6533230..6536144. It has the cytological map location 47B1. Based on sequence similarity, it is predicted to have molecular function</span>: proteasome activator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: proteasome assembly; RNA elongation from RNA polymerase II promoter. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 794 amino acids

    Gene Ontology:
    Cellular Component: proteasome complex [ISS]
    Biological Process: proteasome assembly [ISS]
    RNA elongation from RNA polymerase II promoter [ISS]
    Molecular Function: proteasome activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVENLHTSV ACNRCTECAD WGPNGWIAYG ACNAIAIMDP KFQGNSAKVL FTLVEHTKRV  60
   61 NTVRWLDCDK LLSGGDDAIA ILWELDETGT TKSFTLKGHT SGVNTVDGIR QQDGSWLLAT 120
  121 AAADTTIKLW TFQDNNYVCF QTISLSDGFC FCLRLQLLPK SNQVLLAFSG DDETVSLWSE 180
  181 QVETAGEGDS LGRQFQRKHK LTGHEDWVRG LDFVVDGEDL LLASGSQDNF IRLWRIAPRS 240
  241 KEQMQENRVD LHQLSHNDDE IKVEEKILQL GKEAWYAVSL ESVLYGHEGW IYGVHWHKTP 300
  301 DQELRLLSAS IDKTVIIWAP TEEGIWLEEV RVGEVGGNSV GFYGGKFSGD GHSIMAHSYQ 360
  361 GGFHIWSQDP DRPQLWTPGV IVGGHYGEVR DLAWEHSGAY LMTASADQTT RLHAPWLQDG 420
  421 ANPTWHELAR PQIHGYDMQA LALLSRYKFA SGAEEKIVRT FQAPANFIEN FRHISGIEND 480
  481 DAGDVLLDSL PKGASVPSLG LSNKAVYKVD SEVESTSKTS KDEYPDNYFV PIALETPPQE 540
  541 ETLMQNTLWP ELQKLYGHGY EIFALAATAD GSLLASTCKA SNAEHAQIIL WNPSNWKQIQ 600
  601 KLSGHQLTVT QLSFSPDSRY LLSVSRDRRW CLYERQDSSV SYQLVASTDK SNGVHTRIIW 660
  661 SCDWSHDGQF FVTSSRDGKV VVWKKEEDCK ESSLNGWQAN GVLELKNESI TAVAFSNSYL 720
  721 SGTDDTYILA LGTETGLIKI YQFVRGAWKL LSDLNKSQAH HLTVRRLQFR PGKQLQLASC 780
  781 GEDHLVRIYD IKLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] PSI-BLAST 64.30103 PAF-AH Holoenzyme: Lis1/Alfa2
    2 View Details [125..686] PSI-BLAST 50.154902 Actin interacting protein 1
    3 View Details [687..794] PSI-BLAST 53.221849 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • snoRNA binding
    		•  5.36667333535383 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.13054264433898 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.00646122159505 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.17819869145391 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.4866444894826 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.21305848427711 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle