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Protein Overview: Orc6-PA

General Information:
Name(s) found: Orc6-PA / FBpp0087566 [FlyBase]
Description(s) found:
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  • gi|7303844|gb|AAF58890.1| origin recognition complex subunit 6 [Drosophila melanogaster] [NCBI NR]
  • gi|17946044|gb|AAL49065.1| RE52740p [Drosophila melanogaster] [NCBI NR]
  • gi|17137482|ref|NP_477319.1| origin recognition complex subunit 6 [Drosophila melanogaster] [NCBI NR]
  • gi|13124391|sp|Q9Y1B2.2|ORC6_DROME RecName: Full=Origin recognition complex subunit 6 [NCBI NR]
  • Origin recognition complex subunit 6 OS=Drosophila melanogaster GN=Orc6 PE=1 SV=2 [Swiss-Prot]
  • The gene Origin recognition complex subunit 6 is referred to in FlyBase by the symbol Dmel\Orc6 (CG1584, FBgn0023180). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5732945..5733964. It has the cytological map location 46B4. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: DNA replication initiation; mitosis; DNA replication; M phase of mitotic cell cycle. 14 alleles are reported. The phenotypes of these alleles are annotated with: embryonic salivary gland; imaginal disc; larval brain; larval optic lobe. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG1584-PA translation from_gene[CG1584 Orc6 FBgn0023180] seq_release:3 mol_weight=29239 cds_boundaries:(2R:4,906,201..4,907,027[-]) aa_length:257 transcript_info:[CG1584-RA seq_release:3] gene_info:[gene symbol:Orc6 FBgn0023180 gene_boundaries:(2R:4,9 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9Y1B2) Origin recognition complex subunit 6 [DrosMelano7227.FASTAC.txt]
  • (AE003832) Orc6 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1584-PA [Drosophila melanogaster]gi|17946044|gb|AAL49065.1| RE52740p [Drosophila melanogaster]gi|17137482|ref|NP_477319.1| CG1584-PA [Drosophila melanogaster]gi|13124391|sp|Q9Y1B2|ORC6_DROME Origin recognition complex subunit 6 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(5733070..5733778,5733835..5733899); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890; MD5=4 [fly-100309-contam.fasta]
  • Origin recognition complex subunit 6 CG1584-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1584-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE52740p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Origin recognition complex subunit 6 [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(5733070..5733778,5733835..5733899); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5733070..5733778,5733835..5733899); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Origin recognition complex subunit 6 OS=Drosophila melanogaster GN=Orc6 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(5733070..5733778,5733835..5733899); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890,FlyMine:FBpp0087566,modMine:FBpp0087566; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(9846330..9846394,9845565..9846273)); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890,FlyMine:FBpp0087566,modMine:FBpp0087566; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(9846330..9846394,9845565..9846273)); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890,FlyMine:FBpp0087566,modMine:FBpp0087566; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087566 type=protein; loc=2R:complement(join(9846330..9846394,9845565..9846273)); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890,FlyMine:FBpp0087566,modMine:FBpp0087566; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(9846330..9846394,9845565..9846273)); ID=FBpp0087566; name=Orc6-PA; parent=FBgn0023180,FBtr0088482; dbxref=FlyBase:FBpp0087566,FlyBase_Annotation_IDs:CG1584-PA,GB_protein:AAF58890.1,REFSEQ:NP_477319,GB_protein:AAF58890,UniProt/Swiss-Prot:Q9Y1B2,FlyMine:FBpp0087566,modMine:FBpp0087566; MD5=4ad38732df822c149b1581be3c9a5df0; length=257; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 257 amino acids

    Gene Ontology:
    Cellular Component: origin recognition complex [IDA]
    nuclear origin of replication recognition complex [IDA][ISS][NAS]
    Biological Process: DNA replication initiation [IDA][ISS]
    M phase of mitotic cell cycle [IMP]
    DNA replication [IDA][IEA]
    DNA-dependent DNA replication [NAS]
    mitosis [IMP]
    chromatin silencing [NAS]
    Molecular Function: DNA binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLIEQLIT KMGLREEPNV LEKTTELVRL LELRSTNVPL QINEYGKIVL CADLASCMIG  60
   61 IAFDKEQALK LSGLRKSQYL NNKRMFEKLL DLNKLASVND ICVQLGLNEV ARKAEELMTL 120
  121 FKGVAATEDM GTDTSHPQYA TMAVFQACRL LKKKVSKSKL MPFSNLRPSQ FQLLEQQWER 180
  181 MIAKHHKESK VPSSTDMEGK LKENQNENIK GHEAKKAHKP PPEDYEIWKA RMLAKAQAKL 240
  241 KELEASQSHM DSQLLEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..257] FFAS03 0.96 CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.75688185850223 bayes_pls_golite062009
  • binding
    		•  2.37916921859542 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.37399236069363 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.06743451505655 bayes_pls_golite062009
  • DNA binding
    		•  1.95321993038755 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.41828738664896 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  1.41497909264171 bayes_pls_golite062009
  • protein binding
    		•  1.37207701115974 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22628491144894 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  1.21941169140389 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.18590233040331 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.962670695182671 bayes_pls_golite062009
  • transcription factor binding
    		•  0.655253705928308 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.461517963237846 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0843751392410543 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0606514459376675 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle