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Protein Overview: Myd88-PA, FBpp03...

General Information:
Name(s) found: FBpp0311274 [FlyBase]
FBpp0305215 [FlyBase]
Myd88-PA / FBpp0087679 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • type=protein; loc=2R:complement(5191399..5191840,5192479..5192665,5192739..5192907,5192972..5193261,5194774..5195299); ID=FBpp0311274; name=Myd88-PC; parent=FBgn0033402,FBtr0345024; dbxref=FlyBase:FBpp0311274,FlyBase_Annotation_IDs:CG2078-PC; MD5=365b836c3473ca0db1e6d166be040c07; length=537; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2R:complement(5191399..5191840,5192479..5192665,5192739..5192907,5192972..5193261,5194774..5195299); ID=FBpp0305215; name=Myd88-PB; parent=FBgn0033402,FBtr0333000; dbxref=REFSEQ:NP_001260821,GB_protein:AGB93354,FlyBase:FBpp0305215,FlyBase_Annotation_IDs:CG2078-PB; MD5=365b836c3473ca0db1e6d166be040c07; length=537; release=r5.56; species=Dmel; [FlyBase]
  • The gene Myd88 is referred to in FlyBase by the symbol Dmel\Myd88 (CG2078, FBgn0033402). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5191183..5196181. It has the cytological map location 45C5. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: dorsal/ventral pattern formation. 53 alleles are reported. The phenotypes of these alleles are annotated with: filzkorper; denticle belt. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: intrinsic to membrane [IEA]
    Biological Process: Toll signaling pathway [TAS]
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [NAS]
    immune response [TAS]
    signal transduction [IEA][NAS]
    innate immune response [IEA][NAS]
    response to fungus [TAS]
    defense response [NAS]
    antifungal humoral response [NAS]
    dorsal/ventral pattern formation [IMP]
    Molecular Function: protein binding [IPI]
    transmembrane receptor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPRFVCHQQ HSVAHSHYQP HSHFHHHTHR HPNPPHHHHI YGATDVSYRR YRTAGMVVAE  60
   61 GVMDSGSGSG TGTGLGHFNE TPLSALGIET RTQLSRMLNR KKVLRSEEGY QRDWRGISEL 120
  121 AKQKGFVDEN ANNPMDLVLI SWSQRSPQTA KVGHLEHFLG IIDRWDVCDD IQENLAKDTQ 180
  181 RFIMKQEQRQ TALVEACPPP PSDCFETNNN YSSSNNITVG QSVQILSDED QRCVQMGQPL 240
  241 PRYNACVLYA EADIDHATEI MNNLESERYN LRLFLRHRDM LMGVPFEHVQ LSHFMATRCN 300
  301 HLIVVLTEEF LRSPENTYLV NFTQKIQIEN HTRKIIPILY KTDMHIPQTL GIYTHIKYAG 360
  361 DSKLFNFWDK LARSLHDLDA FSIYSTRQVQ TPSPVEESAP RVTTPSIRIQ INDKDVTDMP 420
  421 NYNSCKVPEA ETTIVSVSGD TGSPLPEHKP KKKDRFLRRI THSFGKTARS DGASGKTLRH 480
  481 AHSVSTINVT ERERTLSASS SNISTTSESK KSFIKWQPNI LKKALFSRSS SKLQTPG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 6.30103 No description for 2o6rA was found.
    2 View Details [198..383] PSI-BLAST 32.154902 Toll-like receptor 2, TLR2
    3 View Details [384..537] MSA 3.235996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • double-stranded RNA binding
    		•  4.32086914489227 bayes_pls_golite062009
  • siRNA binding
    		•  3.8837709376582 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.46815521682665 bayes_pls_golite062009
  • binding
    		•  2.31499720771829 bayes_pls_golite062009
  • protein binding
    		•  2.10005190551596 bayes_pls_golite062009
  • receptor activity
    		•  1.91178122133017 bayes_pls_golite062009
    		• 1.86047705807897 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  1.79927076993237 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.68133457503491 bayes_pls_golite062009
  • DNA binding
    		•  1.10666978727222 bayes_pls_golite062009
  • RNA binding
    		•  0.964496567264848 bayes_pls_golite062009
  • signal transducer activity
    		•  0.574489626172021 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.574489626172021 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.0787292540642052 bayes_pls_golite062009
  • growth factor activity
    		•  0.0066769104515047 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle