Protein Overview: Su(var)2-10-PE

General Information:
Name(s) found:	Su(var)2-10-PE / FBpp0087657 [FlyBase]
Description(s) found: Found 23 descriptions. SHOW ALL	The gene Suppressor of variegation 2-10 is referred to in FlyBase by the symbol Dmel\Su(var)2-10 (CG8068, FBgn0003612). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5003631..5009507. It has the cytological map location 45A8-45A9. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: compound eye development; chromosome organization; chromosome condensation. 21 alleles are reported. The phenotypes of these alleles are annotated with: eye; polytene chromosome; border follicle cell. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	522 amino acids
Gene Ontology:
Cellular Component:	polytene chromosome, telomeric region [IDA] nucleus [IDA][TAS] polytene chromosome [IDA] cytoplasm [IDA][TAS] nuclear lamina [IDA] nucleoplasm [IDA]
Biological Process:	chromosome organization [IMP][TAS] hemopoiesis [TAS] chromosome condensation [IMP] regulation of protein catabolic process [TAS] regulation of JAK-STAT cascade [TAS] compound eye development [IMP][TAS] negative regulation of JAK-STAT cascade [NAS] imaginal disc growth [TAS]
Molecular Function:	nucleic acid binding [IEA] DNA binding [ISS] zinc ion binding [IEA] DEAD/H-box RNA helicase binding [NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQMLRVVEL QKILSFLNIS FAGRKTDLQS RILSFLRTNL ELLAPKVQEV YAQSVQEQNA  60
   61 TLQYIDPTRM YSHIQLPPTV QPNPVGLVGS GQGVQVPGGQ MNVVGGAPFL HTHSINSQLP 120
  121 IHPDVRLKKL AFYDVLGTLI KPSTLVPRNT QRVQEVPFYF TLTPQQATEI ASNRDIRNSS 180
  181 KVEHAIQVQL RFCLVETSCD QEDCFPPNVN VKVNNKLCQL PNVIPTNRPN VEPKRPPRPV 240
  241 NVTSNVKLSP TVTNTITVQW CPDYTRSYCL AVYLVKKLTS TQLLQRMKTK GVKPADYTRG 300
  301 LIKEKLTEDA DCEIATTMLK VSLNCPLGKM KMLLPCRAST CSHLQCFDAS LYLQMNERKP 360
  361 TWNCPVCDKP AIYDNLVIDG YFQEVLGSSL LKSDDTEIQL HQDGSWSTPG LRSETQILDT 420
  421 PSKPAQKVEV ISDDIELISD DAKPVKRDLS PAQDEQPTST SNSETVDLTL SDSDDDMPLA 480
  481 KRRPPAKQAV ASSTSNGSGG GQRAYTPAQQ PQQSGTLDPF LQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
SUMO ligase activity	7.09211721404578	bayes_pls_golite062009
small conjugating protein ligase activity	5.19208367271658	bayes_pls_golite062009
acid-amino acid ligase activity	4.23914967265256	bayes_pls_golite062009
transcription regulator activity	3.41663142583782	bayes_pls_golite062009
DNA binding	3.10342439340038	bayes_pls_golite062009
nucleic acid binding	3.06883460395012	bayes_pls_golite062009
binding	2.85946414867169	bayes_pls_golite062009
transcription repressor activity	2.74753557795928	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.29668422758615	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.24838171947021	bayes_pls_golite062009
transcription corepressor activity	2.19580341360526	bayes_pls_golite062009
transcription coactivator activity	2.00568376574074	bayes_pls_golite062009
transcription factor binding	1.87393007510949	bayes_pls_golite062009
transcription cofactor activity	1.74991817705903	bayes_pls_golite062009
steroid hormone receptor binding	1.6614513749396	bayes_pls_golite062009
hormone receptor binding	1.54663504907102	bayes_pls_golite062009
protein binding	1.4634286530239	bayes_pls_golite062009
androgen receptor binding	1.42204964058772	bayes_pls_golite062009
transcription activator activity	1.33699031660219	bayes_pls_golite062009
nuclear hormone receptor binding	1.31532203831033	bayes_pls_golite062009
chromatin binding	0.65047159761755	bayes_pls_golite062009
receptor binding	0.52768617849698	bayes_pls_golite062009
catalytic activity	0.454272578060498	bayes_pls_golite062009
ligase activity	0.36302660895622	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..118]	PSI-BLAST	15.0	Solution structure of human p53 binding domain of PIAS-1
2	View Details	[119..183]	deduced	N/A	No confident structure predictions are available.
3	View Details	[184..306]	MSA	2.136985	View MSA. No confident structure predictions are available.
4	View Details	[307..394]	PSI-BLAST	10.69897	No description for 2yu4A was found.
5	View Details	[395..522]	MSA	1.093995	View MSA. No confident structure predictions are available.

Protein Overview: Su(var)2-10-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: