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Protein Overview: babo-PA

General Information:
Name(s) found: babo-PA / FBpp0087740 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene baboon is referred to in FlyBase by the symbol Dmel\babo (CG8224, FBgn0011300). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4839846..4850301. It has the cytological map location 44F11-44F12. There is experimental evidence that it has the molecular function</span>: activin binding. There is experimental evidence that it is involved in the biological process</span>: activin receptor signaling pathway; axon guidance; neuron development; eye-antennal disc morphogenesis; regulation of mitotic cell cycle; neuroblast proliferation; imaginal disc-derived wing morphogenesis; mushroom body development. 36 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: adult segment; multi-cell-component structure; nervous system; organ system; peripheral nervous system; adult brain; spiracle; external compound sense organ; larval head segment; integumentary specialisation; adult mesothoracic segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 601 amino acids

    Gene Ontology:
    Cellular Component: activin receptor complex [IPI][ISS]
    plasma membrane [NAS]
    Biological Process: mushroom body development [IMP]
    signal transduction [ISS]
    transforming growth factor beta receptor signaling pathway [ISS]
    imaginal disc-derived wing morphogenesis [IMP]
    eye-antennal disc morphogenesis [IGI]
    axon guidance [IMP]
    response to UV [IDA]
    neuron development [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    positive regulation of multicellular organism growth [TAS]
    regulation of mitotic cell cycle [IMP]
    dendrite morphogenesis [NAS]
    activin receptor signaling pathway [IDA]
    neuroblast proliferation [IMP]
    Molecular Function: ATP binding [IEA]
    activin binding [IDA]
    G-protein coupled receptor kinase activity [ISS]
    activin receptor activity, type I [ISS]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [NAS]
    transforming growth factor beta receptor activity, type I [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSALRLIFL GALLGASVCA SPIEFVMDTS LNGSRSDPAT ATHPGKWPPT TKAPALRAPA  60
   61 GTAGHAYQSP SSSLAADNRS HDNNNASAVS MLLPQDGDAS GAVAPAVTPQ LPIYIAQPSA 120
  121 KKPENKIKCH CDTCKESNNI CETDGFCFTS VEKNSDGSII FSYSCMVVKY NMQRSKPFEC 180
  181 LTSNERFDTY RIDCCKSDFC NKNEIMKRIF ETDYVPHRLT SWEFVAIILG ATLFICFTGT 240
  241 STWYYCQRRK RMASGRTFAK EDSAYDPILN GNTTIHDIIE MTTSGSGSAG LPLLVQRSIA 300
  301 RQVQLCHVIG KGRFGEVWRG RWRGENVAVK IFSSREECSW FREAEIYQTV MLRHENILGF 360
  361 IAADNKDNGT WTQLWLVTDY HENGSLFDYL TTHPVDTNTM LNMSLSIATG LAHLHMDIVG 420
  421 TRGKPAIAHR DLKSKNILVK SNLSCAIGDL GLAVRHVEKN DSVDIPSTHR VGTKRYMAPE 480
  481 VLDESMNDQH FDSYKRADVY AFGLILWEIA RRCNMGMIYD EYQLPYYDVV QPDPSIEEMK 540
  541 KVVCIEKCRP NIPNRWHASD VLHNMAKVMK ECWYPNPVAR LTALRIKKTL ASISVEDKVK 600
  601 N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] deduced N/A No confident structure predictions are available.
    2 View Details [99..254] PSI-BLAST 4.09691 Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
    3 View Details [255..601] PSI-BLAST 74.69897 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transmembrane receptor protein serine/threonine kinase binding
    		•  6.65587066706146 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  6.65587066706146 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  2.91714500246524 bayes_pls_golite062009
  • receptor activity
    		•  2.74055213309696 bayes_pls_golite062009
  • U-plasminogen activator receptor activity
    		•  2.67622889349209 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.63843756028069 bayes_pls_golite062009
  • signal transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • binding
    		•  2.42849959483419 bayes_pls_golite062009
  • protein binding
    		•  2.27773193148456 bayes_pls_golite062009
  • growth factor binding
    		•  2.11370016324137 bayes_pls_golite062009
  • SMAD binding
    		•  2.11166655078306 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.93573786819729 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.8615627852658 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.72562399286061 bayes_pls_golite062009
  • cytokine binding
    		•  1.30600639196836 bayes_pls_golite062009
  • receptor binding
    		•  0.899783960746717 bayes_pls_golite062009
  • enzyme binding
    		•  0.61951403712284 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.227519165953748 bayes_pls_golite062009
  • pattern binding
    		•  0.21003196804615 bayes_pls_golite062009
    3
    Term Confidence Notes
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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