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View Structure Prediction Details

Protein: babo-PA
Organism: Drosophila melanogaster
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for babo-PA.

Description E-value Query
Range
Subject
Range
gi|1079139, gi|4... - gi|436961|gb|AAA18959.1| transmembrane serine/threonine kinase, pir||A55921 serine/threonine kinase ...
452.0 [0..1] [601..1]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSALRLIFL GALLGASVCA SPIEFVMDTS LNGSRSDPAT ATHPGKWPPT TKAPALRAPA  60
   61 GTAGHAYQSP SSSLAADNRS HDNNNASAVS MLLPQDGD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [99-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASGAVAPAVT PQLPIYIAQP SAKKPENKIK CHCDTCKESN NICETDGFCF TSVEKNSDGS  60
   61 IIFSYSCMVV KYNMQRSKPF ECLTSNERFD TYRIDCCKSD FCNKNEIMKR IFETDYVPHR 120
  121 LTSWEFVAII LGATLFICFT GTSTWYYCQR RKRMAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.09691
Match: 1rewC
Description: Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor protein serine/threonine kinase binding 6.65587066706146 bayes_pls_golite062009
transforming growth factor beta receptor binding 6.65587066706146 bayes_pls_golite062009
transforming growth factor beta binding 2.91714500246524 bayes_pls_golite062009
receptor activity 2.74055213309696 bayes_pls_golite062009
U-plasminogen activator receptor activity 2.67622889349209 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.63843756028069 bayes_pls_golite062009
signal transducer activity 2.51859905018984 bayes_pls_golite062009
molecular transducer activity 2.51859905018984 bayes_pls_golite062009
binding 2.42849959483419 bayes_pls_golite062009
protein binding 2.27773193148456 bayes_pls_golite062009
growth factor binding 2.11370016324137 bayes_pls_golite062009
SMAD binding 2.11166655078306 bayes_pls_golite062009
glycosaminoglycan binding 1.93573786819729 bayes_pls_golite062009
type I transforming growth factor beta receptor binding 1.8615627852658 bayes_pls_golite062009
polysaccharide binding 1.72562399286061 bayes_pls_golite062009
cytokine binding 1.30600639196836 bayes_pls_golite062009
receptor binding 0.899783960746717 bayes_pls_golite062009
enzyme binding 0.61951403712284 bayes_pls_golite062009
receptor signaling protein activity 0.227519165953748 bayes_pls_golite062009
pattern binding 0.21003196804615 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [255-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRTFAKEDSA YDPILNGNTT IHDIIEMTTS GSGSAGLPLL VQRSIARQVQ LCHVIGKGRF  60
   61 GEVWRGRWRG ENVAVKIFSS REECSWFREA EIYQTVMLRH ENILGFIAAD NKDNGTWTQL 120
  121 WLVTDYHENG SLFDYLTTHP VDTNTMLNMS LSIATGLAHL HMDIVGTRGK PAIAHRDLKS 180
  181 KNILVKSNLS CAIGDLGLAV RHVEKNDSVD IPSTHRVGTK RYMAPEVLDE SMNDQHFDSY 240
  241 KRADVYAFGL ILWEIARRCN MGMIYDEYQL PYYDVVQPDP SIEEMKKVVC IEKCRPNIPN 300
  301 RWHASDVLHN MAKVMKECWY PNPVARLTAL RIKKTLASIS VEDKVKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.69897
Match: 1b6cB
Description: Type I TGF-beta receptor R4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleotide binding 1.63195828048121 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle