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Protein Overview: PGRP-SC1a-PA, PG...

General Information:
Name(s) found: FBpp0308436 [FlyBase]
PGRP-SC1b-PA / FBpp0087787 [FlyBase]
PGRP-SC1a-PA / FBpp0087786 [FlyBase]
Description(s) found:
Found 65 descriptions.
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  • type=protein; loc=2R:4600981..4601538; ID=FBpp0308436; name=PGRP-SC1b-PB; parent=FBgn0033327,FBtr0339336; dbxref=FlyBase:FBpp0308436,FlyBase_Annotation_IDs:CG8577-PB; MD5=77d2472f17a1ea873a2e65d6f37caeae; length=185; release=r5.56; species=Dmel; [FlyBase]
  • The gene PGRP-SC1b is referred to in FlyBase by the symbol Dmel\PGRP-SC1b (CG8577, FBgn0033327). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4600949..4601587. It has the cytological map location 44E2. There is experimental evidence that it has the molecular function</span>: N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidoglycan catabolic process; innate immune response. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • The gene PGRP-SC1a is referred to in FlyBase by the symbol Dmel\PGRP-SC1a (CG14746, FBgn0043576). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4597268..4597825. It has the cytological map location 44E2. Based on sequence similarity, it is predicted to have molecular function</span>: peptidoglycan binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidoglycan catabolic process; innate immune response; immune response. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 185 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    extracellular region [ISS]
    Biological Process: immune response [ISS]
    peptidoglycan catabolic process [ISS]
    innate immune response [ISS][TAS]
    detection of bacterium [NAS]
    defense response [NAS]
    Molecular Function: peptidoglycan binding [IDA][ISS][NAS][TAS]
    protein binding [IEA]
    N-acetylmuramoyl-L-alanine amidase activity [IDA][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSKVALLLA VLVCSQYMAQ GVYVVSKAEW GGRGAKWTVG LGNYLSYAII HHTAGSYCET  60
   61 RAQCNAVLQS VQNYHMDSLG WPDIGYNFLI GGDGNVYEGR GWNNMGAHAA EWNPYSIGIS 120
  121 FLGNYNWDTL EPNMISAAQQ LLNDAVNRGQ LSSGYILYGH RQVSATECPG THIWNEIRGW 180
  181 SHWSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 47.221849 Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidoglycan binding
    		•  9.32313496679335 bayes_pls_golite062009
  • peptidoglycan receptor activity
    		•  6.51660037886232 bayes_pls_golite062009
  • pattern recognition receptor activity
    		•  6.45255811818702 bayes_pls_golite062009
  • N-acetylmuramoyl-L-alanine amidase activity
    		•  5.29207604418857 bayes_pls_golite062009
  • pattern binding
    		•  4.06455798515101 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.20235326428146 bayes_pls_golite062009
  • receptor activity
    		•  2.69681086194598 bayes_pls_golite062009
  • signal transducer activity
    		•  2.24692953747972 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.24692953747972 bayes_pls_golite062009
  • binding
    		•  1.78736719382897 bayes_pls_golite062009
  • muramyl dipeptide binding
    		•  1.16811676642278 bayes_pls_golite062009
  • hydrolase activity
    		•  1.14017500144843 bayes_pls_golite062009
    		• 0.808368163500401 bayes_pls_golite062009
  • catalytic activity
    		•  0.628556091191359 bayes_pls_golite062009
    		• 0.60706691535931 bayes_pls_golite062009
  • protein binding
    		•  0.175384917086218 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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