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Protein Overview: CSN4-PB, CSN4-PA

General Information:
Name(s) found: CSN4-PB / FBpp0290448 [FlyBase]
CSN4-PA / FBpp0087935 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene COP9 complex homolog subunit 4 is referred to in FlyBase by the symbol Dmel\CSN4 (CG8725, FBgn0027054). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3859680..3861604. It has the cytological map location 43F9-44A1. There is experimental evidence that it has the molecular function</span>: protein binding; promoter binding; NEDD8 activating enzyme activity. There is experimental evidence that it is involved in the biological process</span>: protein deneddylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; compound eye photoreceptor cell differentiation; protein stabilization. 8 alleles are reported. The phenotypes of these alleles are annotated with: cephalopharyngeal skeleton; photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene COP9 complex homolog subunit 4 is referred to in FlyBase by the symbol Dmel\CSN4 (CG8725, FBgn0027054). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3859680..3861604. It has the cytological map location 43F9-44A1. There is experimental evidence that it has the molecular function</span>: protein binding; promoter binding; NEDD8 activating enzyme activity. There is experimental evidence that it is involved in the biological process</span>: protein deneddylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; compound eye photoreceptor cell differentiation; protein stabilization. 8 alleles are reported. The phenotypes of these alleles are annotated with: cephalopharyngeal skeleton; photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 407 amino acids

    Gene Ontology:
    Cellular Component: signalosome [IMP][IPI][ISS][NAS][TAS]
    Biological Process: compound eye photoreceptor cell differentiation [IMP]
    protein deneddylation [IMP]
    protein stabilization [IMP]
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
    Molecular Function: protein binding [IPI]
    NEDD8 activating enzyme activity [IMP]
    promoter binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANYGISTA ALRSQLMGLI NFTGTHKDQA DKYRQLLKTV LTNTGQELID GLRLFVEAIV  60
   61 NEHVSLVISR QILNDVGSEL SKLPDDLSKM LSHFTLEKVN PRVISFEEQV AGIRFHLANI 120
  121 YERNQQWRDA ATVLVGIPLE TGQKQYSVEC KLGTYLKIAR LYLEDNDSVQ AELFINRASL 180
  181 LQAETNSEEL QVLYKVCYAR VLDYRRKFIE AAQRYNELSY RKIVDQGERM TALKKALICT 240
  241 VLASAGQQRS RMLATLFKDE RCQHLPAYGI LEKMYLERII RRSELQEFEA LLQDHQKAAT 300
  301 SDGSSILDRA VFEHNLLSAS KLYNNITFEE LGALLDIPAV KAEKIASQMI TEGRMNGHID 360
  361 QISAIVHFEN RELLPQWDRQ IQSLCYQVNS IIEKISVAEP DWMDNLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] MSA 4.377996 View MSA. No confident structure predictions are available.
    2 View Details [138..279] deduced N/A No confident structure predictions are available.
    3 View Details [280..407] PSI-BLAST 11.0 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.09178084244715 bayes_pls_golite062009
  • DNA binding
    		•  4.69269372393889 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.59221092058767 bayes_pls_golite062009
  • transcription factor activity
    		•  4.01234546864709 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.28015281691988 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.23304004014963 bayes_pls_golite062009
  • transcription activator activity
    		•  2.21230033124772 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.40206639526766 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.27763700765562 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.12147035668008 bayes_pls_golite062009
  • transcription factor binding
    		•  0.78051974537344 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.754042916649094 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.59003343009795 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.486434906547244 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle