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Protein Overview: Spn4-PA

General Information:
Name(s) found: Spn4-PA / FBpp0085524 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Serine protease inhibitor 4 is referred to in FlyBase by the symbol Dmel\Spn4 (CG9453, FBgn0028985). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2763409..2766428. It has the cytological map location 42D6. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of peptide hormone processing; negative regulation of endopeptidase activity; negative regulation of protein maturation by peptide bond cleavage. 7 alleles are reported. The phenotype of these alleles is annotated with: cephalopharyngeal skeleton. It has 11 annotated transcripts and 11 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 392 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: negative regulation of protein maturation by peptide bond cleavage [IMP]
    negative regulation of peptide hormone processing [IMP]
    negative regulation of endopeptidase activity [IDA]
    Molecular Function: serine-type endopeptidase inhibitor activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADAAHQEFA RRLALFSINV YGKLSGQKPG ENIVFSPFSI QTCAAMARLG AENETATQLD  60
   61 QGLGLASSDP EQIAHSFHQV LAAYQDSQIL RIANKIFVMD GYQLRQEFDQ LLSKQFLSAA 120
  121 QSVDFSKNVQ AAATINNWVE QRTNHLIKDL VPADVLNSES RLVLVNAIHF KGTWQHQFAK 180
  181 HLTRPDTFHL DGERTVQVPM MSLKERFRYA DLPALDAMAL ELPYKDSDLS MLIVLPNTKT 240
  241 GLPALEEKLR LTTLSQITQS LYETKVALKL PRFKAEFQVE LSEVFQKLGM SRMFSDQAEF 300
  301 GKMLQSPEPL KVSAIIHKAF IEVNEEGTEA AAATGMAVRR KRAIMSPEEP IEFFADHPFT 360
  361 YVLVHQKDLP LFWGSVVRLE ENTFASSEHD EL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] PSI-BLAST 95.045757 Plasminogen activator inhibitor-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • serine-type endopeptidase inhibitor activity
    		•  6.13717785773502 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  6.07523919900796 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  6.01194624525726 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  3.67290572457064 bayes_pls_golite062009
  • protease binding
    		•  2.69747551802498 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.47388770421699 bayes_pls_golite062009
  • binding
    		•  2.02049891212041 bayes_pls_golite062009
  • protein binding
    		•  1.90236643189719 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.61358221181146 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46959492426289 bayes_pls_golite062009
  • DNA binding
    		•  1.31854786197421 bayes_pls_golite062009
  • transporter activity
    		•  1.29851101299849 bayes_pls_golite062009
  • heparin binding
    		•  1.21540270241849 bayes_pls_golite062009
  • receptor activity
    		•  1.1966923866485 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.14424818451335 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12659599250323 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12659599250323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07876412297114 bayes_pls_golite062009
  • receptor binding
    		•  1.0390886965673 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.99559313679422 bayes_pls_golite062009
  • type 2 angiotensin receptor binding
    		•  0.92552398196189 bayes_pls_golite062009
  • collagen binding
    		•  0.307023895861541 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.262958899612658 bayes_pls_golite062009
  • growth factor activity
    		•  0.21183671094477 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle