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Protein Overview: EcR-PC

General Information:
Name(s) found: EcR-PC / FBpp0085353 [FlyBase]
Description(s) found:
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  • gi|24585968|ref|NP_724459.1| ecdysone receptor, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|21626808|gb|AAM68347.1| ecdysone receptor, isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene Ecdysone receptor is referred to in FlyBase by the symbol Dmel\EcR (CG1765, FBgn0000546). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1977924..2056681. It has the cytological map location 42A9-42A12. There is experimental evidence that it has the molecular function</span>: ecdysteroid hormone receptor activity; protein binding; protein heterodimerization activity. There is experimental evidence for 35 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; reproductive process in a multicellular organism; regulation of biological process; neuron differentiation; regulation of metabolic process; muscle organ development; embryonic development via the syncytial blastoderm; central nervous system development; organ morphogenesis. 136 alleles are reported. The phenotypes of these alleles are annotated with 55 unique terms, many of which group under: organ system; adult segment; imaginal precursor; cuticle; cephalopharyngeal skeleton; external compound sense organ; female germline cyst; nervous system; peripheral nervous system; adult mesothoracic segment. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • >CG1765-PC translation from_gene[CG1765 EcR FBgn0000546] seq_release:3 mol_weight=73348 cds_boundaries:(2R:1,231,459..1,269,985[-]) aa_length:669 transcript_info:[CG1765-RC seq_release:3] gene_info:[gene symbol:EcR FBgn0000546 gene_boundaries:(2R:1,229 [hmr_yeast5_DM3-1_pombe.fasta]
  • CG1765-PC, isoform C [Drosophila melanogaster]gi|24585968|ref|NP_724459.1| CG1765-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(1980093..1981238,1981302..1981454,1981515..1981658,1982062..1982576,2018571..2018622); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM6 [fly-100309-contam.fasta]
  • CG1765-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ecdysone receptor CG1765-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(1980093..1981238,1981302..1981454,1981515..1981658,1982062..1982576,2018571..2018622); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(1980093..1981238,1981302..1981454,1981515..1981658,1982062..1982576,2018571..2018622); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform ECR-B2 of Ecdysone receptor OS=Drosophila melanogaster GN=EcR [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(1980093..1981238,1981302..1981454,1981515..1981658,1982062..1982576,2018571..2018622); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347,FlyMine:FBpp0085353,modMine:FBpp0085353; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(6131066..6131117,6094557..6095071,6094010..6094153,6093797..6093949,6092588..6093733)); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347,FlyMine:FBpp0085353,modMine:FBpp0085353; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(6131066..6131117,6094557..6095071,6094010..6094153,6093797..6093949,6092588..6093733)); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347,FlyMine:FBpp0085353,modMine:FBpp0085353; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P34021, Isoform ECR-B2 of Ecdysone receptor OS=Drosophila melanogaster GN=EcR [DROME.fasta.20160308]
  • FBpp0085353 type=protein; loc=2R:complement(join(6131066..6131117,6094557..6095071,6094010..6094153,6093797..6093949,6092588..6093733)); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347,FlyMine:FBpp0085353,modMine:FBpp0085353; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(6131066..6131117,6094557..6095071,6094010..6094153,6093797..6093949,6092588..6093733)); ID=FBpp0085353; name=EcR-PC; parent=FBgn0000546,FBtr0086012; dbxref=FlyBase:FBpp0085353,FlyBase_Annotation_IDs:CG1765-PC,GB_protein:AAM68347.1,REFSEQ:NP_724459,GB_protein:AAM68347,FlyMine:FBpp0085353,modMine:FBpp0085353; MD5=b9d319d39ea2e6cad040d966d05c0a50; length=669; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTCGLVAEL AHYIDAYGRD DLSPSSSLNG YSANESCDAK KSKKGPAPRV QEELCLVCGD  60
   61 RASGYHYNAL TCEGCKGFFR RSVTKSAVYC CKFGRACEMD MYMRRKCQEC RLKKCLAVGM 120
  121 RPECVVPENQ CAMKRREKKA QKEKDKMTTS PSSQHGGNGS LASGGGQDFV KKEILDLMTC 180
  181 EPPQHATIPL LPDEILAKCQ ARNIPSLTYN QLAVIYKLIW YQDGYEQPSE EDLRRIMSQP 240
  241 DENESQTDVS FRHITEITIL TVQLIVEFAK GLPAFTKIPQ EDQITLLKAC SSEVMMLRMA 300
  301 RRYDHSSDSI FFANNRSYTR DSYKMAGMAD NIEDLLHFCR QMFSMKVDNV EYALLTAIVI 360
  361 FSDRPGLEKA QLVEAIQSYY IDTLRIYILN RHCGDSMSLV FYAKLLSILT ELRTLGNQNA 420
  421 EMCFSLKLKN RKLPKFLEEI WDVHAIPPSV QSHLQITQEE NERLERAERM RASVGGAITA 480
  481 GIDCDSASTS AAAAAAQHQP QPQPQPQPSS LTQNDSQHQT QPQLQPQLPP QLQGQLQPQL 540
  541 QPQLQTQLQP QIQPQPQLLP VSAPVPASVT APGSLSAVST SSEYMGGSAA IGPITPATTS 600
  601 SITAAVTASS TTSAVPMGNG VGVGVGVGGN VSMYANAQTA MALMGVALHS HQEQLIGGVA 660
  661 VKSEHSTTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 37.0 No description for 2hanB was found.
    2 View Details [136..452] PSI-BLAST 47.39794 hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
    3 View Details [453..669] FFAS03 1.08 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • receptor activity
    		•  3.23961300660788 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.62296162642478 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.46727132249624 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • signal transducer activity
    		•  2.3211572231948 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.3211572231948 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.91348392022358 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • hormone receptor binding
    		•  1.8288193687002 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.72196998170947 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • androgen receptor binding
    		•  1.48596869620742 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • transporter activity
    		•  1.29143782009237 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  1.28090460550476 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.26313925559554 bayes_pls_golite062009
  • structural molecule activity
    		•  1.1947100233139 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07067346221546 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801223278704275 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle