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View Structure Prediction Details

Protein: EcR-PC
Organism: Drosophila melanogaster
Length: 669 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EcR-PC.

Description E-value Query
Range
Subject
Range
gi|22786171 - gi|22786171|gb|AAG02187.2| synthetic VP16-glucocorticoid/ecdysone receptor VgEcR [Cloning vector pFB...
440.0 [0..18] [669..105]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTCGLVAEL AHYIDAYGRD DLSPSSSLNG YSANESCDAK KSKKGPAPRV QEELCLVCGD  60
   61 RASGYHYNAL TCEGCKGFFR RSVTKSAVYC CKFGRACEMD MYMRRKCQEC RLKKCLAVGM 120
  121 RPECVVPENQ CAMKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
receptor activity 3.23961300660788 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
ion transmembrane transporter activity 2.62296162642478 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.46727132249624 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
signal transducer activity 2.3211572231948 bayes_pls_golite062009
molecular transducer activity 2.3211572231948 bayes_pls_golite062009
nuclear hormone receptor binding 1.91348392022358 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
hormone receptor binding 1.8288193687002 bayes_pls_golite062009
steroid hormone receptor binding 1.72196998170947 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
androgen receptor binding 1.48596869620742 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
transporter activity 1.29143782009237 bayes_pls_golite062009
steroid hormone receptor activity 1.28090460550476 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
structural constituent of ribosome 1.26313925559554 bayes_pls_golite062009
structural molecule activity 1.1947100233139 bayes_pls_golite062009
transmembrane transporter activity 1.07067346221546 bayes_pls_golite062009
substrate-specific transporter activity 0.801223278704275 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [136-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REKKAQKEKD KMTTSPSSQH GGNGSLASGG GQDFVKKEIL DLMTCEPPQH ATIPLLPDEI  60
   61 LAKCQARNIP SLTYNQLAVI YKLIWYQDGY EQPSEEDLRR IMSQPDENES QTDVSFRHIT 120
  121 EITILTVQLI VEFAKGLPAF TKIPQEDQIT LLKACSSEVM MLRMARRYDH SSDSIFFANN 180
  181 RSYTRDSYKM AGMADNIEDL LHFCRQMFSM KVDNVEYALL TAIVIFSDRP GLEKAQLVEA 240
  241 IQSYYIDTLR IYILNRHCGD SMSLVFYAKL LSILTELRTL GNQNAEMCFS LKLKNRKLPK 300
  301 FLEEIWDVHA IPPSVQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.39794
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [453-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLQITQEENE RLERAERMRA SVGGAITAGI DCDSASTSAA AAAAQHQPQP QPQPQPSSLT  60
   61 QNDSQHQTQP QLQPQLPPQL QGQLQPQLQP QLQTQLQPQI QPQPQLLPVS APVPASVTAP 120
  121 GSLSAVSTSS EYMGGSAAIG PITPATTSSI TAAVTASSTT SAVPMGNGVG VGVGVGGNVS 180
  181 MYANAQTAMA LMGVALHSHQ EQLIGGVAVK SEHSTTA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 2j63A
Description: No description for 2j63A was found.

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