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Protein Overview: FBpp0309711, Ned...

General Information:
Name(s) found: FBpp0309711 [FlyBase]
Nedd8-PA / FBpp0080733 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2L:complement(18951241..18951346,18951407..18951537,18951698..18951715); ID=FBpp0309711; name=Nedd8-PB; parent=FBgn0032725,FBtr0342928; dbxref=FlyBase:FBpp0309711,FlyBase_Annotation_IDs:CG10679-PB; MD5=4d6a4c62b11df2a3e1857c18d6e5be6d; length=84; release=r5.56; species=Dmel; [FlyBase]
  • The gene Nedd8 is referred to in FlyBase by the symbol Dmel\Nedd8 (CG10679, FBgn0032725). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:18951147..18951845. It has the cytological map location 37B7. It is reported to have molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: regulation of ubiquitin-protein ligase activity; regulation of protein stability; regulation of smoothened signaling pathway; cell proliferation; regulation of proteolysis. 15 alleles are reported. The phenotype of these alleles is annotated with: mushroom body. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 84 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cell proliferation [IMP]
    regulation of protein stability [IMP]
    regulation of proteolysis [IMP]
    protein modification process [NAS]
    regulation of ubiquitin-protein ligase activity [IMP]
    ubiquitin-dependent protein catabolic process [NAS]
    regulation of smoothened signaling pathway [IMP]
    Molecular Function: protein binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIKVKTLTG KEIEIDIEPT DKVDRIKERV EEKEGIPPQQ QRLIFSGKQM NDDKTAADYK  60
   61 VQGGSVLHLV LALRGGDSIL TPCV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] PSI-BLAST 36.154902 Solution Structure of S5a UIM-1/Ubiquitin Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  7.96815122865454 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  7.5865326390755 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.96506647680367 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.87890364671564 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.80275625219016 bayes_pls_golite062009
  • structural molecule activity
    		•  5.37716040292459 bayes_pls_golite062009
  • ligase activity
    		•  2.98370000660434 bayes_pls_golite062009
  • protein binding
    		•  2.9188688008729 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21955949922709 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9984951714209 bayes_pls_golite062009
  • DNA binding
    		•  1.86539227646379 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.20282717466582 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.06193722939839 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.80391127659342 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.62324312069889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.614233748923048 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • tubulin binding
    		•  0.51378503121967 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • RNA binding
    		•  0.359926300264681 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • microtubule binding
    		•  0.24163565725263 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • transferase activity
    		•  0.236208643697075 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle