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Protein Overview: NC2beta-PA

General Information:
Name(s) found: NC2beta-PA / FBpp0080256 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene NC2Ã?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\NC2Ã?&#142;Ã?² (CG4185, FBgn0028926). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:15007819..15008538. It has the cytological map location 35B8. There is experimental evidence that it has the molecular function</span>: protein binding; transcription repressor activity; transcription activator activity; RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 183 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    negative cofactor 2 complex [NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDA]
    negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [NAS]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    Molecular Function: protein binding [IPI]
    RNA polymerase II transcription factor activity [IDA]
    sequence-specific DNA binding [IEA]
    transcription activator activity [IDA]
    transcription repressor activity [IDA]
    general transcriptional repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNPQEELLP PSAEDDELTL PRASINKIIK ELVPTVRVAN ESRELILNCC SEFIHLISSE  60
   61 ANEVCNMRNK KTINAEHVLE ALERLGFHDY KQEAEAVLHD CKEVAAKRRR QSTRLENLGI 120
  121 PEEELLRQQQ ELFAKAREEQ AREEQQQWMS MQAAAMVQRP PLADGSVASK PSEDDDDDDD 180
  181 DDY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 32.30103 Negative cofactor 2, NC2, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.43582244485566 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription activator activity
    		•  2.58408368884371 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • protein binding
    		•  2.1291876005999 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  1.57176056919918 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.18653213156155 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle