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Protein Overview: Trf-PA

General Information:
Name(s) found: Trf-PA / FBpp0079164 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene TBP-related factor is referred to in FlyBase by the symbol Dmel\Trf (CG7562, FBgn0010287). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:8072897..8073949. It has the cytological map location 28E1. There is experimental evidence that it has the molecular function</span>: RNA polymerase III transcription factor activity; transcription factor binding; specific RNA polymerase II transcription factor activity; RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter. 7 alleles are reported. The phenotypes of these alleles are annotated with: spermatocyte; spermatozoon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome [IDA]
    transcription factor complex [IPI]
    transcription factor TFIID complex [IDA][ISS]
    Biological Process: transcription initiation from RNA polymerase III promoter [IEP]
    regulation of transcription, DNA-dependent [IEA]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of transcription from RNA polymerase III promoter [IDA][TAS]
    transcription initiation from RNA polymerase II promoter [IDA][ISS]
    regulation of transcription from RNA polymerase II promoter [TAS]
    Molecular Function: DNA binding [IDA][TAS]
    RNA polymerase II transcription factor activity [IDA]
    specific RNA polymerase II transcription factor activity [IEP]
    general RNA polymerase II transcription factor activity [ISS]
    transcription factor binding [IPI]
    RNA polymerase III transcription factor activity [IDA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQFHFKVADA ERDRDNVAAT SNAAANPHAA LQPQQPVALV EPKDAQHEIR LQNIVATFSV  60
   61 NCELDLKAIN SRTRNSEYSP KRFRGVIMRM HSPRCTALIF RTGKVICTGA RNEIEADIGS 120
  121 RKFARILQKL GFPVKFMEYK LQNIVATVDL RFPIRLENLN HVHGQFSSYE PEMFPGLIYR 180
  181 MVKPRIVLLI FVNGKVVFTG AKSRKDIMDC LEAISPILLS FRKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 82.69897 Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  10.1927670598446 bayes_pls_golite062009
  • RNA polymerase III transcription factor activity
    		•  8.4318102330583 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.66773099672992 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.97397050058114 bayes_pls_golite062009
  • DNA binding
    		•  3.93251147843671 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.82919607287537 bayes_pls_golite062009
  • binding
    		•  2.72886792846471 bayes_pls_golite062009
  • transcription factor activity
    		•  2.38288562794802 bayes_pls_golite062009
  • protein binding
    		•  1.96605926404517 bayes_pls_golite062009
  • transcription factor binding
    		•  1.86204668268867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.59579825271822 bayes_pls_golite062009
  • transcription activator activity
    		•  1.5285505684695 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.16858275919592 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.312991469396539 bayes_pls_golite062009
  • RNA polymerase I transcription factor activity
    		•  0.230395922046101 bayes_pls_golite062009
  • chromatin binding
    		•  0.107733889697044 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle