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Protein Overview: FBpp0307126, aph...

General Information:
Name(s) found: FBpp0307126 [FlyBase]
aph-1-PA / FBpp0077400 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=2L:join(2766315..2766707,2766767..2767090); ID=FBpp0307126; name=aph-1-PB; parent=FBgn0031458,FBtr0335127; dbxref=FlyBase:FBpp0307126,REFSEQ:NP_001259963,GB_protein:AGB92500,FlyBase_Annotation_IDs:CG2855-PB; MD5=9daf259982dceb86523650e0346b230f; length=238; release=r5.56; species=Dmel; [FlyBase]
  • The gene anterior pharynx defective 1 is referred to in FlyBase by the symbol Dmel\aph-1 (CG2855, FBgn0031458). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2766235..2767154. It has the cytological map location 23A5. There is experimental evidence that it has the molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: Notch signaling pathway. 17 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; embryonic nervous system; wing; microchaeta. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    integral to membrane [IEA]
    plasma membrane [NAS]
    Biological Process: Notch signaling pathway [IMP]
    positive regulation of catalytic activity [IEA]
    protein processing [IEA]
    Molecular Function: protein binding [IEA]
    endopeptidase activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLPEFFGCT FIAFGPPFAL FVFTIANDPV RIIILIAAAF FWLLSLLISS LWYALIPLKE  60
   61 FLAFGVVFSV CFQEAFRYII YRILRSTEQG LHAVAEDTRV TDNKHILAYV SGLGFGIISG 120
  121 MFALVNVLAD MSGPGTMGLK GGTELFFVTS AAQALSIILL HTFWSVIFFN AFDTNNYIHI 180
  181 GYVVFSHLFV SLITLLNANE LYTTTLLINY LVTILTGVLA FRVAGGTSRS FRKFITCQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] MSA 4.017957 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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