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Protein Overview: AIF1_RAT

General Information:
Name(s) found: AIF1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|972909|gb|AAA80105.1| allograft inflammatory factor-1 [NCBI NR]
  • gi|8392881|ref|NP_058892.1| allograft inflammatory factor 1 [Rattus norvegicus] [NCBI NR]
  • gi|46237622|emb|CAE83999.1| allograft inflammatory factor 1 [Rattus norvegicus] [NCBI NR]
  • pir||I55617 allograft inflammatory factor-1 - rat [NCBI NR]
  • gi|1817520|dbj|BAA19189.1| MRF-1 [Rattus norvegicus] [NCBI NR]
  • gi|1703218|sp|P55009.1|AIF1_RAT RecName: Full=Allograft inflammatory factor 1; Short=AIF-1; AltName: Full=Ionized calcium-binding adapter molecule 1; AltName: Full=Microglia response factor; AltName: Full=MRF-1 [NCBI NR]
  • gi|149028090|gb|EDL83541.1| allograft inflammatory factor 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149028089|gb|EDL83540.1| allograft inflammatory factor 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • Allograft inflammatory factor 1 OS=Rattus norvegicus GN=Aif1 PE=2 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):20-4796561;20-4796561 Allograft inflammatory factor-1 [hmr_yeast5_DM3-1_pombe.fasta]
  • allograft inflammatory factor 1; balloon angioplasty responsive transcript; ionized calcium binding adapter molecule 1 [HMR_022704-rand.fasta]
  • allograft inflammatory factor 1 [Rattus norvegicus]gi|8392881|ref|NP_058892.1| allograft inflammatory factor 1 [Rattus norvegicus]gi|2143576|pir||I55617 allograft inflammatory factor-1 - ratgi|972909|gb|AAA80105.1| allograft inflammatory factor-1gi|18 [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Allograft inflammatory factor 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_017196) allograft inflammatory factor 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 Allograft inflammatory factor-1 [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Microglia response factor) (MRF-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • allograft inflammatory factor 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • allograft inflammatory factor 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MRF-1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • allograft inflammatory factor-1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 ALLOGRAFT INFLAMMATORY FACTOR-1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Aif1 Allograft inflammatory factor 1 [rat-ipi-250309-contam.fasta]
  • Allograft inflammatory factor 1 OS=Rattus norvegicus GN=Aif1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    cytoplasm [UNKNOWN][IEA]
    ruffle [UNKNOWN]
    cytosol [IDA]
    ruffle membrane [UNKNOWN][ISS]
    actin filament [UNKNOWN][ISS]
    perikaryon [IDA]
    phagocytic cup [UNKNOWN][IEA]
    cell projection [IDA]
    plasma membrane [IEA]
    lamellipodium [IDA]
    Biological Process: response to cytokine stimulus [IEP]
    positive regulation of nitric oxide biosynthetic process [IDA][IMP]
    response to axon injury [IEP]
    macrophage activation [NAS]
    positive regulation of smooth muscle cell proliferation [IMP]
    negative regulation of gene expression [IMP]
    cellular response to extracellular stimulus [IEP]
    negative regulation of apoptosis [IDA][IMP]
    positive regulation of protein amino acid phosphorylation [IMP]
    positive regulation of muscle hyperplasia [IMP]
    response to glucocorticoid stimulus [IEP]
    cellular response to hormone stimulus [IEP]
    response to electrical stimulus [IEP]
    actin filament bundle assembly [UNKNOWN][IEA][ISS]
    cellular response to chemical stimulus [IEP]
    positive regulation of cell migration [IDA][IMP]
    Molecular Function: actin filament binding [UNKNOWN][ISS]
    protein binding [UNKNOWN][IEA]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSKDLQGG KAFGLLKAQQ EERLDGINKH FLDDPKYSSD EDLQSKLEAF KTKYMEFDLN  60
   61 GNGDIDIMSL KRMLEKLGVP KTHLELKKLI REVSSGSEET FSYSDFLRMM LGKRSAILRM 120
  121 ILMYEEKNKE HQKPTGPPAK KAISELP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 23.0 Crystal structure of microglia-specific protein, Iba1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle