Protein Overview: HIF1A_RAT

General Information:
Name(s) found:	HIF1A_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|32469606\|sp\|O35800.1\|HIF1A_RAT RecName: Full=Hypoxia-inducible factor 1 alpha; Short=HIF-1 alpha; Short=HIF1 alpha [NCBI NR] gi\|2632131\|emb\|CAA70701.1\| hypoxia-inducible factor 1 [Rattus norvegicus] [NCBI NR] (O35800) Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) [Swiss-Prot] Hypoxia-inducible factor 1-alpha OS=Rattus norvegicus GN=Hif1a PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Hypoxia-inducible factor 1 [hmr_yeast5_DM3-1_pombe.fasta] hypoxia-inducible factor 1 [Rattus norvegicus]gi\|32469606\|sp\|O35800\|HIFA_RAT Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Hypoxia-inducible factor 1 alpha [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] hypoxia-inducible factor 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Hif1a Hypoxia-inducible factor 1 alpha [rat-ipi-250309-contam.fasta] Hypoxia-inducible factor 1-alpha OS=Rattus norvegicus GN=Hif1a [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	825 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IDA][IEA][ISS][TAS] transcription factor complex [UNKNOWN] cytoplasm [UNKNOWN][IDA] microtubule-based flagellum [UNKNOWN] nucleolus [UNKNOWN]
Biological Process:	negative regulation of growth [UNKNOWN] muscle cell homeostasis [UNKNOWN] embryonic hemopoiesis [UNKNOWN] positive regulation of cell proliferation [IMP] positive regulation of transcription [UNKNOWN][ISS] lactate metabolic process [UNKNOWN] regulation of transforming growth factor-beta2 production [UNKNOWN] regulation of transcription [UNKNOWN] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA] positive regulation of erythrocyte differentiation [UNKNOWN] embryonic placenta development [UNKNOWN] cellular iron ion homeostasis [UNKNOWN] cellular response to insulin stimulus [IEP] positive regulation of smooth muscle cell proliferation [IMP] response to glucose stimulus [IEP] response to hypoxia [UNKNOWN][IDA][ISS] positive regulation of gene-specific transcription [UNKNOWN] angiogenesis [UNKNOWN] positive regulation of vascular endothelial growth factor receptor signaling pathway [UNKNOWN] regulation of catalytic activity [UNKNOWN] heart looping [UNKNOWN] oxygen homeostasis [UNKNOWN] positive regulation vascular endothelial growth factor production [UNKNOWN] response to muscle activity [UNKNOWN] regulation of transcription from RNA polymerase II promoter in response to oxidative stress [UNKNOWN][IMP] signal transduction [UNKNOWN][IEA] positive regulation of hormone biosynthetic process [UNKNOWN] regulation of transcription, DNA-dependent [UNKNOWN][IEA][TAS] hemoglobin biosynthetic process [UNKNOWN] regulation of apoptosis [UNKNOWN] neural crest cell migration [UNKNOWN] glucose homeostasis [UNKNOWN] regulation of gene expression [UNKNOWN] cell differentiation [UNKNOWN] cartilage development [UNKNOWN]
Molecular Function:	histone acetyltransferase binding [UNKNOWN][ISS] double-stranded DNA binding [TAS] sequence-specific DNA binding [UNKNOWN][IDA] transcription factor binding [UNKNOWN] signal transducer activity [IEA] DNA binding [UNKNOWN] transcription factor activity [UNKNOWN][IEA] protein binding [UNKNOWN] RNA polymerase II transcription factor activity [TAS] protein heterodimerization activity [UNKNOWN][IDA][ISS] specific RNA polymerase II transcription factor activity [IDA] RNA polymerase II transcription factor activity, enhancer binding [UNKNOWN] Hsp90 protein binding [UNKNOWN] protein complex binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM  60
   61 RLTISYLRVR KLLDAGDLDI EDEMKAQMNC FYLKAPDGFV MVLTDDGDMI YISDNVNKYM 120
  121 GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGPVRKGKE QNTQRSFFLR MKCTLTSRGR 180
  181 TMNIKSATWK VLHCTGHIHV YDTSSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK 240
  241 TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 300
  301 TTGQYRMLAK RGGYVWVETQ ATVIYNTKDS QPQCIVCVNY VVSGIIQHDL IFSLQQTESV 360
  361 LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL APAAGDTIIS LDFGSDDTET 420
  421 EDQQLEDVPL YNDVMFPSSN EKLNINLAMS PLPASETPKP LRSSADPALN QEVALKLESS 480
  481 PESLGLSFTM PQIQDQPASP SDGSTRQSSP EPNSPSEYCF DVDSDMVNVF KLELVEKLFA 540
  541 EDTEAKNPFS AQDTDLDLEM LAPYIPMDDD FQLRSFDQLS PLESNSPSPP SVSTVTGFQQ 600
  601 TQLQKPTITV TAATATTATT TDESKAVTKD NIEDIKILIA SPPSTQVPQE MTTAKASAYS 660
  661 GTHSRTASPD RAGKRVIEKT DKAHPRSLNL SVTLNQRNTV PEEELNPRTI ALQNAQRKRK 720
  721 MEHDGSLFQA AGIGTLLQQP GDRAPTMSLS WKRVKGYISS EQDGMEQKTI FLIPSDLACR 780
  781 LLGQSMDESG LPQLTSYDCE VNAPIQGSRN LLQGEELLRA LDQVN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: HIF1A_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: