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Protein Overview: GHR_RAT

General Information:
Name(s) found: GHR_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Growth hormone receptor OS=Rattus norvegicus GN=Ghr PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 638 amino acids

    Gene Ontology:
    Cellular Component: receptor complex [UNKNOWN]
    neuronal cell body [IDA]
    extracellular region [IEA]
    plasma membrane [UNKNOWN][IDA]
    cell surface [UNKNOWN][IEA]
    growth hormone receptor complex [UNKNOWN][IEA]
    nucleus [UNKNOWN][IDA]
    integral to plasma membrane [UNKNOWN][IEA]
    extracellular space [UNKNOWN][IDA]
    cytoplasm [IDA]
    mitochondrion [IDA]
    integral to membrane [UNKNOWN]
    extrinsic to membrane [UNKNOWN][IEA]
    Biological Process: response to food [IEP]
    response to cytokine stimulus [IEP]
    activation of JAK2 kinase activity [IDA]
    neuroprotection [IDA]
    citrate metabolic process [IEA]
    response to cycloheximide [UNKNOWN]
    multicellular organismal metabolic process [UNKNOWN][IEA]
    succinate metabolic process [IEA]
    creatine metabolic process [IEA]
    2-oxoglutarate metabolic process [IEA]
    positive regulation of multicellular organism growth [UNKNOWN][IEA]
    allantoin metabolic process [IEA]
    JAK-STAT cascade [IDA]
    hormone-mediated signaling pathway [IDA]
    cellular response to insulin stimulus [IEP]
    activation of MAPK activity [IDA]
    response to glucocorticoid stimulus [IEP]
    positive regulation of peptidyl-tyrosine phosphorylation [IEA]
    growth hormone receptor signaling pathway [UNKNOWN][IDA]
    cartilage development involved in endochondral bone morphogenesis [IEP]
    insulin-like growth factor receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of cell differentiation [IEP][TAS]
    valine metabolic process [IEA]
    response to morphine [IEP]
    endocytosis [IEA]
    response to hormone stimulus [IEP]
    response to peptide hormone stimulus [IEP]
    fatty acid metabolic process [IEA]
    positive regulation of JAK-STAT cascade [IDA][IMP]
    creatinine metabolic process [IEA]
    isoleucine metabolic process [IEA]
    oxaloacetate metabolic process [IEA]
    response to estradiol stimulus [UNKNOWN]
    response to interleukin-1 [IEP]
    taurine metabolic process [IEA]
    cellular response to hormone stimulus [UNKNOWN]
    [NOT]receptor internalization [UNKNOWN]
    Molecular Function: protein kinase binding [IDA][IPI]
    growth factor binding [UNKNOWN]
    protein binding [UNKNOWN][IEA]
    protein phosphatase binding [IMP][IPI]
    protein homodimerization activity [UNKNOWN][IEA]
    growth hormone receptor activity [UNKNOWN][IDA][TAS]
    peptide hormone binding [UNKNOWN][IDA]
    receptor activity [IEA]
    SH2 domain binding [IDA][IMP][IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLWRVFLTL ALAVSSDMFP GSGATPATLG KASPVLQRIN PSLRESSSGK PRFTKCRSPE  60
   61 LETFSCYWTE GDDHNLKVPG SIQLYYARRI AHEWTPEWKE CPDYVSAGAN SCYFNSSYTS 120
  121 IWIPYCIKLT TNGDLLDEKC FTVDEIVQPD PPIGLNWTLL NISLPGIRGD IQVSWQPPPS 180
  181 ADVLKGWIIL EYEIQYKEVN ETKWKTMSPI WSTSVPLYSL RLDKEHEVRV RSRQRSFEKY 240
  241 SEFSEVLRVT FPQMDTLAAC EEDFRFPWFL IIIFGIFGVA VMLFVVIFSK QQRIKMLILP 300
  301 PVPVPKIKGI DPDLLKEGKL EEVNTILGIH DNYKPDFYND DSWVEFIELD IDDADEKTEE 360
  361 SDTDRLLSDD QEKSAGILGA KDDDSGRTSC YDPDILDTDF HTSDMCDGTS EFAQPQKLKA 420
  421 EADLLCLDQK NLKNSPYDAS LGSLHPSITL TMEDKPQPLL GSETESTHQL PSTPMSSPVS 480
  481 LANIDFYAQV SDITPAGGVV LSPGQKIKAG LAQGNTQLEV AAPCQENYSM NSAYFCESDA 540
  541 KKCIAAAPHM EATTCVKPSF NQEDIYITTE SLTTTARMSE TADTAPDAEP VPDYTTVHTV 600
  601 KSPRGLILNA TALPLPDKKK FLSSCGYVST DQLNKIMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle