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Protein Overview: PRRX1_RAT

General Information:
Name(s) found: PRRX1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|51702771|sp|P63014.1|PRRX1_RAT RecName: Full=Paired mesoderm homeobox protein 1; AltName: Full=Paired-related homeobox protein 1; Short=PRX-1; Short=rHox [NCBI NR]
  • gi|24429584|ref|NP_722543.1| paired related homeobox 1 [Rattus norvegicus] [NCBI NR]
  • gi|149058222|gb|EDM09379.1| paired related homeobox 1, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • Paired mesoderm homeobox protein 1 OS=Rattus norvegicus GN=Prrx1 PE=1 SV=1 [Swiss-Prot]
  • (P63014) Paired mesoderm homeobox protein 1 (PRX-1) (Paired related homeobox protein 1) (rHox) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):13-69590213 Splice isoform PMX1-B of P43271 [hmr_yeast5_DM3-1_pombe.fasta]
  • paired related homeobox 1; paired mesoderm homeobox 1 [HMR_022704-rand.fasta]
  • paired related homeobox 1 [Mus musculus]gi|24429584|ref|NP_722543.1| paired related homeobox 1 [Rattus norvegicus]gi|51362|emb|CAA42410.1| DNA-binding protein [Mus musculus]gi|284740|pir||S26076 homeotic protein K-2a - mousegi|1836044|gb|AAB46839.1| r [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Paired mesoderm homeobox protein 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Paired mesoderm homeobox protein 1 (Paired-related homeobox protein 1) (PRX-1) (rHox) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • paired related homeobox 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • paired related homeobox 1, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PAIRED MESODERM HOMEOBOX PROTEIN 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Paired mesoderm homeobox protein 1 (PRX-1) (Paired-related homeobox protein 1) (rHox) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Prrx1 Paired mesoderm homeobox protein 1 [rat-ipi-250309-contam.fasta]
  • Paired mesoderm homeobox protein 1 OS=Rattus norvegicus GN=Prrx1 [011711_HMR.fasta]
  • Paired mesoderm homeobox protein 1 OS=Rattus norvegicus GN=Prrx1 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 245 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    Biological Process: multicellular organismal development [IEA]
    palate development [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IEA]
    middle ear morphogenesis [UNKNOWN][IEA]
    embryonic cranial skeleton morphogenesis [UNKNOWN][IEA]
    artery morphogenesis [UNKNOWN][IEA]
    positive regulation of mesenchymal cell proliferation [UNKNOWN][IEA]
    embryonic skeletal system morphogenesis [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    embryonic limb morphogenesis [UNKNOWN][IEA]
    inner ear morphogenesis [UNKNOWN][IEA]
    positive regulation of smoothened signaling pathway [UNKNOWN][IEA]
    cartilage development [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [IEA]
    sequence-specific DNA binding [IEA]
    transcription repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA  60
   61 GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 120
  121 AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 180
  181 PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ 240
  241 VPTVN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] PSI-BLAST 23.69897 Paired protein
    2 View Details [158..245] MSA 2.450995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.529774583092406 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle