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View Structure Prediction Details

Protein: PRRX1_RAT
Organism: Rattus norvegicus
Length: 245 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRRX1_RAT.

Description E-value Query
Range
Subject
Range
gi|114565328 - gi|114565328|ref|XP_001141191.1| PREDICTED: paired mesoderm homeobox 1 isoform 2 [Pan troglodytes]
PRRX1 - paired related homeobox 1
gi|109019461 - gi|109019461|ref|XP_001097390.1| PREDICTED: similar to paired mesoderm homeobox 1 isoform pmx-1b iso...
CCDS1290.1_1 - null
gi|167773485 - gi|167773485|gb|ABZ92177.1| paired related homeobox 1 [synthetic construct]
155.0 [0..1] [245..1]
gi|126165288, gi... - gi|76637309|ref|XP_871943.1| PREDICTED: similar to paired related homeobox 1 isoform 2 [Bos taurus],...
152.0 [0..1] [245..1]
PRRX1_CHICK - Paired mesoderm homeobox protein 1 OS=Gallus gallus GN=PRRX1 PE=1 SV=2
145.0 [0..1] [245..1]
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
144.0 [0..3] [182..28]
gi|2696969 - gi|2696969|dbj|BAA24022.1| PAX6 LS [Cynops pyrrhogaster]
143.0 [0..3] [231..152]
gi|3402201 - gi|3402201|emb|CAA16493.1| PAX6 [Takifugu rubripes]
142.0 [0..3] [245..141]
gi|5758937 - gi|5758937|gb|AAD50902.1|AF169413_1 paired-box transcription factor +- isoform [Ambystoma mexicanum]
140.0 [0..3] [231..133]
gi|2369653 - gi|2369653|emb|CAA68836.1| PAX-6 protein [Astyanax mexicanus]
140.0 [0..3] [245..144]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA  60
   61 GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 120
  121 AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.529774583092406 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANKNASLLKS YSGDVTAVEQ PIVPRPAPRP TDYLSWGTAS PYSAMATYSA TCANNSPAQG  60
   61 INMANSIANL RLKAKEYSLQ RNQVPTVN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle