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Protein Overview: TGFR2_RAT

General Information:
Name(s) found: TGFR2_RAT [Swiss-Prot]
Description(s) found:
Found 18 descriptions.
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  • TGF-beta receptor type-2 OS=Rattus norvegicus GN=Tgfbr2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 567 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDA]
    caveola [UNKNOWN][IMP]
    cytoplasm [IDA]
    membrane [IEA]
    transforming growth factor beta receptor complex [IC]
    external side of plasma membrane [UNKNOWN]
    integral to membrane [UNKNOWN][IEA]
    cytosol [IDA]
    receptor complex [UNKNOWN][IEA]
    plasma membrane [UNKNOWN]
    cell surface [IDA]
    Biological Process: embryonic development [IEP]
    negative regulation of cardiac muscle cell proliferation [IMP]
    trachea formation [UNKNOWN]
    response to estrogen stimulus [IEP]
    mammary gland morphogenesis [UNKNOWN]
    transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA][IMP][TAS]
    response to glucose stimulus [IEP]
    wound healing [IEP]
    response to hypoxia [IEP][TAS]
    in utero embryonic development [UNKNOWN]
    gut development [IEP]
    response to cholesterol [UNKNOWN]
    common-partner SMAD protein phosphorylation [IDA]
    response to organic substance [IEP]
    smoothened signaling pathway [UNKNOWN]
    response to nutrient [IEP]
    trachea morphogenesis [UNKNOWN]
    response to organic cyclic substance [IEP]
    bronchus development [UNKNOWN]
    receptor-mediated endocytosis [IDA]
    bronchus morphogenesis [UNKNOWN]
    positive regulation of tolerance induction to self antigen [UNKNOWN]
    organ morphogenesis [IMP]
    organ regeneration [IEP]
    peptidyl-serine phosphorylation [UNKNOWN]
    peptidyl-threonine phosphorylation [UNKNOWN]
    positive regulation of NK T cell differentiation [UNKNOWN]
    lung lobe morphogenesis [UNKNOWN]
    negative regulation of cell proliferation [IGI][IMP]
    vasculogenesis [IEP]
    protein amino acid phosphorylation [UNKNOWN][IEA]
    pathway-restricted SMAD protein phosphorylation [UNKNOWN]
    positive regulation of B cell tolerance induction [UNKNOWN]
    response to mechanical stimulus [IEP]
    lung morphogenesis [UNKNOWN]
    positive regulation of smooth muscle cell proliferation [IMP]
    heart development [UNKNOWN]
    patterning of blood vessels [UNKNOWN]
    myeloid dendritic cell differentiation [UNKNOWN]
    activation of protein kinase activity [UNKNOWN]
    lung development [UNKNOWN][IEP]
    response to steroid hormone stimulus [IEP]
    aging [IEP]
    embryo implantation [IEP]
    regulation of cell proliferation [UNKNOWN]
    positive regulation of skeletal muscle tissue regeneration [IEP]
    gastrulation [UNKNOWN]
    positive regulation of T cell tolerance induction [UNKNOWN]
    response to drug [UNKNOWN]
    Molecular Function: protein homodimerization activity [TAS]
    transforming growth factor beta receptor activity [UNKNOWN]
    receptor activity [IEA]
    transforming growth factor beta receptor activity, type II [IEA][IMP][TAS]
    transmembrane receptor protein serine/threonine kinase activity [UNKNOWN]
    nucleotide binding [IEA]
    transforming growth factor beta binding [UNKNOWN]
    ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [IEA]
    protein binding [UNKNOWN][IPI]
    SMAD binding [UNKNOWN]
    glycosaminoglycan binding [UNKNOWN]
    metal ion binding [IEA]
    protein heterodimerization activity [TAS]
    transferase activity [IEA]
    mitogen-activated protein kinase kinase kinase binding [IPI]
    type III transforming growth factor beta receptor binding [UNKNOWN]
    type I transforming growth factor beta receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST  60
   61 CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT 120
  121 CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQVTGV SLLPPLGIAI 180
  181 AVIAIFYCYR VHRQQKLSPS WESSKPRKLM DFSDNCAIIL EDDRSDISST CANNINHNTE 240
  241 LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYSSWKTE KDIFSDINLK 300
  301 HENILQFLTA EERKTEMGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 360
  361 LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420
  421 TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480
  481 HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QIVCETLTEC WDHDPEARLT AQCVAERFSE 540
  541 LEHPDRLSGR SCSQEKIPED GSLNTTK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.16

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle