Protein Overview: SMAD7_RAT

General Information:
Name(s) found:	SMAD7_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|13959529\|sp\|O88406.2\|SMAD7_RAT RecName: Full=Mothers against decapentaplegic homolog 7; Short=Mothers against DPP homolog 7; AltName: Full=SMAD 7; Short=Smad7 [NCBI NR] Mothers against decapentaplegic homolog 7 OS=Rattus norvegicus GN=Smad7 PE=2 SV=2 [Swiss-Prot] (O88406) Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) [Swiss-Prot] Ensembl_locations(Chr-bp):18-14397192 Mothers against decapentaplegic homolog 7 [hmr_yeast5_DM3-1_pombe.fasta] Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Mothers against decapentaplegic homolog 7 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Mothers against decapentaplegic homolog 7 (Mothers against DPP homolog 7) (SMAD 7) (Smad7) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Smad7 Mothers against decapentaplegic homolog 7 [rat-ipi-250309-contam.fasta] Mothers against decapentaplegic homolog 7 OS=Rattus norvegicus GN=Smad7 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	426 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IEA] transcription factor complex [IEA] cytoplasm [UNKNOWN][IEA] cell-cell adherens junction [UNKNOWN][IEA] cytosol [UNKNOWN] catenin complex [UNKNOWN][IEA] intracellular [IEA] plasma membrane [UNKNOWN][IEA]
Biological Process:	ventricular cardiac muscle tissue morphogenesis [IEA] positive regulation of cell-cell adhesion [UNKNOWN][IEA] transforming growth factor beta receptor signaling pathway [UNKNOWN] negative regulation of ubiquitin-protein ligase activity [UNKNOWN][IEA] regulation of activin receptor signaling pathway [UNKNOWN][IEA] cellular protein complex localization [UNKNOWN][IEA] BMP signaling pathway [UNKNOWN] positive regulation of protein ubiquitination [UNKNOWN][IEA] negative regulation of peptidyl-serine phosphorylation [UNKNOWN][IEA] negative regulation of protein ubiquitination [UNKNOWN] negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA] negative regulation of pathway-restricted SMAD protein phosphorylation [UNKNOWN] regulation of transcription, DNA-dependent [IEA] artery morphogenesis [IEA] negative regulation of transcription factor activity [UNKNOWN][IEA] ventricular septum morphogenesis [IEA] negative regulation of BMP signaling pathway [UNKNOWN][IEA] intracellular signaling pathway [IDA] response to laminar fluid shear stress [UNKNOWN][IEA] ureteric bud development [UNKNOWN][IEA] negative regulation of peptidyl-threonine phosphorylation [UNKNOWN][IEA] negative regulation of transcription by competitive promoter binding [UNKNOWN][IEA] negative regulation of transcription [IEP] adherens junction assembly [UNKNOWN][IEA] regulation of transforming growth factor beta receptor signaling pathway [IDA] positive regulation of proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA] protein stabilization [UNKNOWN][IEA] negative regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
Molecular Function:	transcription factor activity [IEA] protein binding [UNKNOWN][IPI] ubiquitin protein ligase binding [UNKNOWN][IPI] activin binding [UNKNOWN][IEA] collagen binding [UNKNOWN][IEA] transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [UNKNOWN][IEA] beta-catenin binding [UNKNOWN][IEA] promoter binding [UNKNOWN][IEA] I-SMAD binding [UNKNOWN][IEA] type I transforming growth factor beta receptor binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRTKRSALV RRLWRSRAPG GEDEEEGVGG GGGGGGLRGE GATDGRAYGA GGGGAGRAGC  60
   61 CLGKAVRGAK GHHHPHPPSS GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG 120
  121 TRTACLLLPG RLDCRLGPGA PASAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC 180
  181 ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTADCPDAVP SSDETGGTNY 240
  241 LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ 300
  301 LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV 360
  361 FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE 420
  421 VIFNSR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: SMAD7_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: