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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein. Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. The process of introducing a phosphate group on to a protein. The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of pathway-restricted SMAD protein phosphorylation
Acc: GO:0060394
Aspect: Biological Process
Desc: Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0060394 - negative regulation of pathway-restricted SMAD protein phosphorylation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle