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Protein Overview: MITF_RAT

General Information:
Name(s) found: MITF_RAT [Swiss-Prot]
Description(s) found:
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  • gi|3319231|gb|AAC26170.1| microphthalmia associated transcription factor [Rattus norvegicus] [NCBI NR]
  • gi|13124329|sp|O88368.1|MITF_RAT RecName: Full=Microphthalmia-associated transcription factor [NCBI NR]
  • Microphthalmia-associated transcription factor (Fragment) OS=Rattus norvegicus GN=Mitf PE=2 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):4-137966943 Microphthalmia-associated transcription factor [hmr_yeast5_DM3-1_pombe.fasta]
  • Microphthalmia-associated transcription factorgi|3319231|gb|AAC26170.1| microphthalmia associated transcription factor [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Microphthalmia-associated transcription factor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • microphthalmia associated transcription factor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Microphthalmia-associated transcription factor (Fragment) OS=Rattus norvegicus GN=Mitf [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 110 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    cellular_component [ND]
    Biological Process: biological_process [ND]
    bone remodeling [UNKNOWN][IEA]
    multicellular organismal development [IEA]
    regulation of transcription, DNA-dependent [UNKNOWN]
    regulation of apoptosis [UNKNOWN]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    regulation of cell proliferation [UNKNOWN][IEA]
    osteoclast differentiation [UNKNOWN]
    melanocyte differentiation [UNKNOWN][IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    negative regulation of apoptosis [UNKNOWN][IEA]
    pigmentation [UNKNOWN][IEA]
    regulation of osteoclast differentiation [UNKNOWN][IEA]
    camera-type eye development [UNKNOWN][IEA]
    cell fate commitment [UNKNOWN][IEA]
    regulation of gene expression [UNKNOWN]
    cell differentiation [UNKNOWN]
    Wnt receptor signaling pathway [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN][IEA]
    transcription factor activity [UNKNOWN]
    transcription regulator activity [IEA]
    RNA polymerase II transcription factor activity, enhancer binding [UNKNOWN][IEA]
    chromatin binding [UNKNOWN][IEA]
    transcription activator activity [UNKNOWN]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTACIFPTES EARALAKERQ KKDNHNLIER RRRFNINDRI KELGTLIPKS NDPDMRWNKG  60
   61 TILKASVDYI RKLQREQQRA KDLENRQKKL EHANRHLLLR VQELEMQARA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 10.09691 Solution Structure of Max B-HLH-LZ

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle