Protein Overview: GDF8_RAT

General Information:
Name(s) found:	GDF8_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9506907\|ref\|NP_062024.1\| myostatin [Rattus norvegicus] [NCBI NR] gi\|6016122\|sp\|O35312.1\|GDF8_RAT RecName: Full=Growth/differentiation factor 8; Short=GDF-8; AltName: Full=Myostatin; Flags: Precursor [NCBI NR] gi\|2623576\|gb\|AAB86691.1\| myostatin; growth/differentiation factor-8; GDF-8 [Rattus norvegicus] [NCBI NR] gi\|149046216\|gb\|EDL99109.1\| growth differentiation factor 8 [Rattus norvegicus] [NCBI NR] Growth/differentiation factor 8 OS=Rattus norvegicus GN=Mstn PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Growth/differentiation factor 8 precursor [hmr_yeast5_DM3-1_pombe.fasta] growth differentiation factor 8; myostatin [HMR_022704-rand.fasta] growth differentiation factor 8 [Rattus norvegicus]gi\|2623576\|gb\|AAB86691.1\| myostatin; growth/differentiation factor-8; GDF-8 [Rattus norvegicus]gi\|6016122\|sp\|O35312\|GDF8_RAT Growth/differentiation factor 8 precursor (GDF-8) (Myostatin) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Growth/differentiation factor 8 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_019151) growth differentiation factor 8; myostatin [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Growth/differentiation factor 8 precursor (GDF-8) (Myostatin) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] myostatin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] growth differentiation factor 8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] myostatin; growth/differentiation factor-8; GDF-8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 GROWTH/DIFFERENTIATION FACTOR 8 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Mstn Growth/differentiation factor 8 [rat-ipi-250309-contam.fasta] myostatin precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Growth/differentiation factor 8 OS=Rattus norvegicus GN=Mstn [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	376 amino acids
Gene Ontology:
Cellular Component:	extracellular space [IDA] cytoplasm [IDA] extracellular region [IEA] cellular_component [ND]
Biological Process:	negative regulation of muscle hypertrophy [IMP] response to muscle activity [IEP] response to estrogen stimulus [IEP] transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA] positive regulation of transcription [UNKNOWN][IEA] ovulation cycle process [IEP] growth [IEA] skeletal muscle tissue regeneration [IEP] response to gravity [IEP] response to ethanol [IEP] response to heat [IEP] negative regulation of skeletal muscle tissue growth [IMP] response to glucocorticoid stimulus [IEP] response to testosterone stimulus [IEP] response to electrical stimulus [IEP] skeletal muscle atrophy [IEP]
Molecular Function:	growth factor activity [IEA] protein binding [UNKNOWN] cytokine activity [IEA] receptor binding [UNKNOWN] molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQKPQMYVY IYLFVLIAAG PVDLNEDSER EANVEKEGLC NACAWRQNTR YSRIEAIKIQ  60
   61 ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII 120
  121 TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRAVKTPTTV FVQILRLIKP 180
  181 MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV 240
  241 TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII 300
  301 APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI 360
  361 IYGKIPAMVV DRCGCS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.66

Protein Overview: GDF8_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: