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Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. Any biological process, occurring at the level of a multicellular organism, pertinent to its function. The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. Any process that modulates the frequency, rate or extent of muscle hypertrophy. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of muscle hypertrophy
Acc: GO:0014741
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014741 - negative regulation of muscle hypertrophy (interactive image map)
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