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Protein Overview: GDF8_RAT

General Information:
Name(s) found: GDF8_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Growth/differentiation factor 8 OS=Rattus norvegicus GN=Mstn PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IDA]
    cytoplasm [IDA]
    extracellular region [IEA]
    cellular_component [ND]
    Biological Process: negative regulation of muscle hypertrophy [IMP]
    response to muscle activity [IEP]
    response to estrogen stimulus [IEP]
    transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of transcription [UNKNOWN][IEA]
    ovulation cycle process [IEP]
    growth [IEA]
    skeletal muscle tissue regeneration [IEP]
    response to gravity [IEP]
    response to ethanol [IEP]
    response to heat [IEP]
    negative regulation of skeletal muscle tissue growth [IMP]
    response to glucocorticoid stimulus [IEP]
    response to testosterone stimulus [IEP]
    response to electrical stimulus [IEP]
    skeletal muscle atrophy [IEP]
    Molecular Function: growth factor activity [IEA]
    protein binding [UNKNOWN]
    cytokine activity [IEA]
    receptor binding [UNKNOWN]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQKPQMYVY IYLFVLIAAG PVDLNEDSER EANVEKEGLC NACAWRQNTR YSRIEAIKIQ  60
   61 ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII 120
  121 TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRAVKTPTTV FVQILRLIKP 180
  181 MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV 240
  241 TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII 300
  301 APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI 360
  361 IYGKIPAMVV DRCGCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle