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Protein Overview: TSC1_RAT

General Information:
Name(s) found: TSC1_RAT [Swiss-Prot]
Description(s) found:
Found 16 descriptions.
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  • Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1163 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IEA]
    growth cone [IDA]
    cytoplasm [UNKNOWN][IEA]
    cell cortex [UNKNOWN][IEA]
    cytoskeletal part [IDA]
    membrane [IEA]
    microsome [IDA]
    cytosol [UNKNOWN][IDA]
    TSC1-TSC2 complex [UNKNOWN][IEA]
    protein complex [UNKNOWN][IDA][IMP]
    actin filament [UNKNOWN][IEA]
    lamellipodium [UNKNOWN][IEA]
    Biological Process: embryonic development [UNKNOWN][IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    cell projection organization [UNKNOWN][IEA]
    nervous system development [UNKNOWN][IEA]
    regulation of stress fiber assembly [UNKNOWN][IMP]
    myelination [UNKNOWN][IEA]
    protein heterooligomerization [IDA]
    regulation of phosphoprotein phosphatase activity [UNKNOWN][IEA]
    regulation of translation [UNKNOWN]
    potassium ion transport [UNKNOWN][IEA]
    response to insulin stimulus [UNKNOWN][IEA]
    neural tube closure [UNKNOWN][IEA]
    kidney development [UNKNOWN][IEA]
    negative regulation of cell size [UNKNOWN][IEA]
    activation of Rho GTPase activity [UNKNOWN][IEA]
    negative regulation of protein ubiquitination [UNKNOWN][IEA]
    negative regulation of TOR signaling pathway [UNKNOWN][IEA]
    negative regulation of translation [UNKNOWN][IEA]
    cardiac muscle cell differentiation [UNKNOWN][IEA]
    cell-matrix adhesion [UNKNOWN]
    regulation of protein kinase activity [UNKNOWN][IEA]
    synapse organization [UNKNOWN][IEA]
    hippocampus development [UNKNOWN][IEA]
    cerebral cortex development [UNKNOWN][IEA]
    rRNA export from nucleus [UNKNOWN][IEA]
    regulation of focal adhesion assembly [IMP]
    regulation of cell-matrix adhesion [UNKNOWN]
    regulation of actin cytoskeleton organization [IMP]
    positive regulation of focal adhesion assembly [UNKNOWN][IEA]
    Molecular Function: protein binding [UNKNOWN][IMP][IPI][TAS]
    protein N-terminus binding [UNKNOWN][IPI]
    chaperone binding [UNKNOWN][IEA]
    GTPase regulator activity [IMP]
    GTPase activating protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQLANIGEL LSMLDSSTLG VRDDVTTIFK ESLNSERGPM LVNTLVDYYL ETNSQPVLHI  60
   61 LTTLQEPHDK HLLDKMNEYV GKAATRLSIL SLLGHVVRLQ PSWKHKLSQA PLLPSLLKCL 120
  121 KMDTDVVVLT TGVLVLITML PMIPQSGKQH LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL 180
  181 HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH 240
  241 ELDPRRWKTL ETHDVVIECA KISLDPTEAS YEDGDAVSHQ LSACFPHRSA DVTTSSYVDT 300
  301 QNSYGGATST PSSTSRLMLF STPGQLPQSL SSLSTRPLPE PLQASLWSPS AVCGMTTPPT 360
  361 SPGNVPADLS HPYSKAFGTT TGGKGTPSGT PATSPPPAPP CPQDDCAHGP ASQASATPPR 420
  421 KEERADSSRP YLPRQQDVPS DRGLEDLPGS KGSVTLRNLP DFLGDLASEE DSIEKDKEEA 480
  481 AISKELSEIT TAEADPVAPR GGFDSPFYRD SLSGSQRKTH SAASGTQGFS VNPEPLHSSL 540
  541 DKHGPDTPKQ AFTPIDPPSG SADASPAGDR DRQTSLETSI LTPSPCKIPP QRGVSFGSGQ 600
  601 LPPYDHLFEV ALPKTACHFV SKKTEELLKK AKGNPEEDCV PSTSPMEVLD RLLEQGAGAH 660
  661 SKELSRLSLP SKSVDWTHFG GSPPSDEIRT LRDQLLLLHN QLLYERFKRQ QHALRNRRLL 720
  721 RKVIRAAALE EHNAAMKDQL KLQEKDIQMW KVSLQKEQAR YSQLQQQRDT MVTQLHSQIR 780
  781 QLQHDREEFY NQSQELQTKL EDCRSMIAEL RVELKKANSK VCHTELLLSQ VSQKLSNSES 840
  841 VQQQMEFLNR QLLVLGEVNE LYLEQLQSKH PDTTKEVEMM KTAYRKELEK NRSHLLQQNQ 900
  901 RLDASQRRVL ELESLLAKKD HLLLEQKKYL EDVKSQASGQ LLAAESRYEA QRKITRVLEL 960
  961 EILDLYGRLE KDGRLQKLEE DRAEAAEAAE ERLDCCTDGC SDSLLGHNEE AAGHNGETRT1020
 1021 SRPGGTRASC GGRVTGGSSS SSSELSTPEK PPNQRFSSRW EPTMGEPSSS IPTTVGSLPS1080
 1081 SKSFLGMKTR ELFRNKSESQ CDEDGMTMSS FSETLKTELG KDSAGMENKT PPSLDAPHPS1140
 1141 SPSSDSMGQL HIMDYNETHH EHS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle