Protein Overview: ITPR3_RAT

General Information:
Name(s) found:	ITPR3_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981110\|ref\|NP_037270.1\| inositol 1,4,5-triphosphate receptor, type 3 [Rattus norvegicus] [NCBI NR] pir\|\|A46719 inositol 1,4,5-trisphosphate receptor subtype 3 - rat [NCBI NR] gi\|310171\|gb\|AAA41446.1\| inositol triphosphate receptor subtype 3 [NCBI NR] gi\|17365979\|sp\|Q63269.1\|ITPR3_RAT RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; AltName: Full=Type 3 InsP3 receptor; AltName: Full=IP3 receptor isoform 3; AltName: Full=InsP3R3; Sho [NCBI NR] Inositol 1,4,5-trisphosphate receptor type 3 OS=Rattus norvegicus GN=Itpr3 PE=1 SV=1 [Swiss-Prot] (Q63269) Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3) (IP3R-3) [Swiss-Prot] Ensembl_locations(Chr-bp):None Inositol 1,4,5-trisphosphate receptor type 3 [hmr_yeast5_DM3-1_pombe.fasta] inositol 1, 4, 5-triphosphate receptor 3 [HMR_022704-rand.fasta] inositol 1, 4, 5-triphosphate receptor 3 [Rattus norvegicus]gi\|17365979\|sp\|Q63269\|IP3T_RAT Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3) (IP3R-3)gi\| [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Inositol 1,4,5-trisphosphate receptor type 3 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_013138) inositol 1, 4, 5-triphosphate receptor 3 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3) (IP3R-3) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] inositol 1,4,5-triphosphate receptor 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] inositol triphosphate receptor subtype 3 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] inositol 1,4,5-triphosphate receptor, type 3 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] inositol 1, 4, 5-triphosphate receptor 3 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Itpr3 Inositol 1,4,5-trisphosphate receptor type 3 [rat-ipi-250309-contam.fasta] Inositol 1,4,5-trisphosphate receptor type 3 OS=Rattus norvegicus GN=Itpr3 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	2670 amino acids
Gene Ontology:
Cellular Component:	myelin sheath [IDA] platelet dense tubular network membrane [UNKNOWN] microsome [UNKNOWN][IEA] nuclear outer membrane [IDA] endoplasmic reticulum [IDA] neuronal cell body [IDA] nucleolus [UNKNOWN][IEA] nucleoplasm [UNKNOWN][IEA] endoplasmic reticulum membrane [UNKNOWN] nucleus [UNKNOWN][IEA] integral to plasma membrane [UNKNOWN][IEA] brush border [IDA] apical part of cell [IDA] cytoplasm [UNKNOWN][IDA] membrane [IEA]
Biological Process:	ion transport [IEA] transmembrane transport [IEA] G-protein coupled receptor protein signaling pathway [IDA] sensory perception of umami taste [UNKNOWN][IEA] response to calcium ion [UNKNOWN][IEA] calcium ion transport [UNKNOWN][IEA] sensory perception of sweet taste [UNKNOWN][IEA] sensory perception of bitter taste [UNKNOWN][IEA] protein homooligomerization [IDA] protein heterooligomerization [IDA] elevation of cytosolic calcium ion concentration [IDA]
Molecular Function:	ion channel activity [IEA] inositol-1,4,5-trisphosphate receptor activity [UNKNOWN][TAS] protein binding [UNKNOWN][IEA] calcium channel activity [IEA] inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [UNKNOWN][IDA] calcium ion transmembrane transporter activity [TAS] phosphoinositide binding [UNKNOWN][IEA] inositol hexakisphosphate binding [IDA] inositol 1,3,4,5 tetrakisphosphate binding [IDA] inositol 1,4,5 trisphosphate binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC  60
   61 PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 120
  121 VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 180
  181 DKVILNPVNA GQPLHASNYE LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 240
  241 VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 300
  301 NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI KYRLVAVPHG 360
  361 NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNAPIDVEEE RPIRLMLGTC 420
  421 PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 480
  481 FFVSDVPNNG QNVLDIMVTK PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE 540
  541 LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 600
  601 NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE LICKCVLDPK 660
  661 NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA 720
  721 HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISKQLGVELL FLCMADEMLP FDLRASFCHL 780
  781 MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY 840
  841 LNNVVGEAVP FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 900
  901 VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ LDRSKFEDNE 960
  961 HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSST1020
 1021 ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLL HLTMHDYPPL VSGALQLLFK1080
 1081 HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE1140
 1141 AGASKDKKER PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM1200
 1201 DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL QLFLTPGLLE1260
 1261 AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL DFLHTVIKAE GKYVKKCQDM1320
 1321 IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN1380
 1381 VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL1440
 1441 FENFTLDMAL VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ1500
 1501 LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA LLSSGGSCSA1560
 1561 AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDM1620
 1621 LHWPELLFLE GSEAYQRCES GGFLSKLIRH TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG1680
 1681 DRGNQLRKML LQNYLQNRKS GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL1740
 1741 ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET1800
 1801 KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG HDVSERAQNN1860
 1861 EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG1920
 1921 LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL1980
 1981 CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN2040
 2041 SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK2100
 2101 SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET KHRLFTTTEQ2160
 2161 DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF2220
 2221 FYPYVEGAST GVLGSPLISL LFWILICFSI AALFTKHYSV RPLIVALVLR SIYYLGIGPT2280
 2281 LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY2340
 2341 SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR2400
 2401 LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST ERACDTLLMC2460
 2461 IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA2520
 2521 DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT2580
 2581 DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA2640
 2641 QLNELKEQMT EQRKRRQRLG FVDVQNCMSR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ITPR3_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: