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Protein Overview: E2AK2_RAT

General Information:
Name(s) found: E2AK2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|9506993|ref|NP_062208.1| eukaryotic translation initiation factor 2-alpha kinase 2 [Rattus norvegicus] [NCBI NR]
  • gi|81910551|sp|Q63184.1|E2AK2_RAT RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; AltName: Full=Interferon-inducible RNA-dependent protein kinase; AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Sho [NCBI NR]
  • gi|468373|gb|AAA61926.1| RNA-dependent initiation factor-2 kinase [NCBI NR]
  • pir||S50216 translation initiation factor eIF-2 alpha chain kinase (EC 2.7.1.-) - rat [NCBI NR]
  • Interferon-induced, double-stranded RNA-activated protein kinase OS=Rattus norvegicus GN=Eif2ak2 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):6-1926205 RNA-dependent initiation factor-2 kinase [hmr_yeast5_DM3-1_pombe.fasta]
  • Protein kinase, interferon-inducible double stranded RNA dependent [HMR_022704-rand.fasta]
  • Protein kinase, interferon-inducible double stranded RNA dependent [Rattus norvegicus]gi|1085566|pir||S50216 translation initiation factor eIF-2 alpha chain kinase (EC 2.7.1.-) - ratgi|468373|gb|AAA61926.1| RNA-dependent initiation factor-2 kinase [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 RNA-dependent initiation factor-2 kinase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_019335) Protein kinase, interferon-inducible double stranded RNA dependent [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Interferon-induced, double-stranded RNA-activated protein kinase (Interferon-inducible RNA-dependent protein kinase) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Protein kinase RNA-activated) (PKR) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • eukaryotic translation initiation factor 2-alpha kinase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • RNA-dependent initiation factor-2 kinase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 RNA-DEPENDENT INITIATION FACTOR-2 KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Protein kinase, interferon-inducible double stranded RNA dependent [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase [rat-ipi-250309-contam.fasta]
  • Interferon-induced, double-stranded RNA-activated protein kinase OS=Rattus norvegicus GN=Eif2ak2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 513 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    soluble fraction [IDA]
    intracellular [IEA]
    Biological Process: response to organic substance [IEP]
    response to vitamin E [IPI]
    protein amino acid autophosphorylation [UNKNOWN]
    protein amino acid phosphorylation [UNKNOWN][IEA]
    response to virus [IEA]
    response to toxin [IMP]
    translation [UNKNOWN]
    response to mechanical stimulus [IEP]
    endoplasmic reticulum unfolded protein response [UNKNOWN]
    response to exogenous dsRNA [IEP]
    virus-infected cell apoptosis [UNKNOWN]
    positive regulation of apoptosis [IMP]
    response to lipopolysaccharide [IMP]
    negative regulation of osteoblast proliferation [UNKNOWN][ISS]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN][IPI]
    double-stranded RNA binding [IEA]
    protein kinase activity [UNKNOWN]
    protein serine/threonine kinase activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASDTPGFYV DKLNKYSQIH KVKIIYKEIS VTGPPHDRRF TFQVIIEERE FPEGEGRSKQ  60
   61 EAKNNAAKLA VEILDNENKV DSHTDASEQG LIEGNYIGLV NSFAQKENLP VNFELCDPDS 120
  121 QLPHRFICKC KIGQTTYGTG FGANKKEAKQ LAAKNAYQKL SEKSPSKTGF VTSLSSDFSS 180
  181 SSSITSNSAS QSASGRDFED IFMNGLREKR KSGVKVPSDD VLRNKYTLDD RFSKDFEDIE 240
  241 EIGSGGFGQV FKAKHRIDGK TYAIKRITYN TKKAKREVQA LAELNHANIV QYRVCWEGED 300
  301 YDYDPENSTN GDTSRYKTRC LFIQMEFCDK GTLQQWLEKR NRSQEDKALV LELFEQIVTG 360
  361 VDYIHSKGLI HRDLKPGNIF LVDEKHIKIG DFGLATALEN DGNPRTKYTG TPQYMSPEQK 420
  421 SSLVEYGKEV DIFALGLILA ELLHICKTDS EKIEFFQLLR NGIFSDDIFD NKEKSLLQKL 480
  481 LSSKPRERPN TSEILKTLAE WKNISEKKKR NTC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle