Protein Overview: AT1A2_RAT

General Information:
Name(s) found:	AT1A2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|B24639 Na+/K+-exchanging ATPase (EC 3.6.3.9) alpha-2 chain - rat [NCBI NR] gi\|6978545\|ref\|NP_036637.1\| Na+/K+ -ATPase alpha 2 subunit [Rattus norvegicus] [NCBI NR] gi\|55250732\|gb\|AAH85764.1\| ATPase, Na+/K+ transporting, alpha 2 polypeptide [Rattus norvegicus] [NCBI NR] gi\|203029\|gb\|AAA40776.1\| (Na+ and K+) ATPase, alpha+ catalytic subunit precursor [NCBI NR] gi\|149040740\|gb\|EDL94697.1\| rCG20216, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|114379\|sp\|P06686.1\|AT1A2_RAT RecName: Full=Sodium/potassium-transporting ATPase subunit alpha-2; Short=Sodium pump subunit alpha-2; AltName: Full=Na(+)/K(+) ATPase alpha-2 subunit; AltName: Full=Na(+)/K(+) ATPase alpha(+) subunit; Flags: Precursor [NCBI NR] Sodium/potassium-transporting ATPase subunit alpha-2 OS=Rattus norvegicus GN=Atp1a2 PE=1 SV=1 [Swiss-Prot] (P06686) Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)) [Swiss-Prot] Ensembl_locations(Chr-bp):13-79122046 Sodium/potassium-transporting ATPase alpha-2 chain precursor [hmr_yeast5_DM3-1_pombe.fasta] ATPase, Na+K+ transporting, alpha 2; ATPase Na+K+ transporting alpha 2 polypeptide [HMR_022704-rand.fasta] ATPase, Na+K+ transporting, alpha 2 [Rattus norvegicus]gi\|6978545\|ref\|NP_036637.1\| ATPase, Na+K+ transporting, alpha 2 [Rattus norvegicus]gi\|30409956\|ref\|NP_848492.1\| ATPase, Na+/K+ transporting, alpha 2 polypeptide [Mus musculus]gi\|23274024\|gb\|AAH3612 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Sodium/potassium-transporting ATPase alpha-2 chain precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012505) ATPase, Na+K+ transporting, alpha 2 polypeptide [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] ATPase, Na+/K+ transporting, alpha 2 polypeptide [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Sodium/potassium-transporting ATPase subunit alpha-2 precursor (Sodium pump subunit alpha-2) (Na(+)/K(+) ATPase alpha-2 subunit) (Na(+)/K(+) ATPase alpha(+) subunit) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] rCG20216, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] (Na+ and K+) ATPase, alpha+ catalytic subunit precursor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-2 CHAIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Na+/K+ -ATPase alpha 2 subunit [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Sodium/potassium-transporting ATPase alpha-2 chain precursor (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 [rat-ipi-250309-contam.fasta] Sodium/potassium-transporting ATPase subunit alpha-2 OS=Rattus norvegicus GN=Atp1a2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1020 amino acids
Gene Ontology:
Cellular Component:	microsome [UNKNOWN][IEA] sodium:potassium-exchanging ATPase complex [IDA] synapse [IDA] neuron projection [IDA] plasma membrane [UNKNOWN][IMP] membrane fraction [IDA] caveola [IDA] endosome [IDA] cytoplasm [UNKNOWN][IEA] sarcolemma [UNKNOWN][IEA] membrane [IEA] dendritic spine [IDA] integral to membrane [IEA]
Biological Process:	monovalent inorganic cation transport [IEA] ATP hydrolysis coupled proton transport [IMP] locomotion [UNKNOWN][IEA] metabolic process [IEA] ATP catabolic process [TAS] reduction of cytosolic calcium ion concentration [UNKNOWN][IEA] adult locomotory behavior [UNKNOWN][IEA] visual learning [UNKNOWN][IEA] regulation of respiratory gaseous exchange by neurological system process [UNKNOWN][IEA] ATP biosynthetic process [IEA] negative regulation of striated muscle contraction [UNKNOWN][IEA] regulation of striated muscle contraction [UNKNOWN] regulation of blood pressure [UNKNOWN][IEA] regulation of smooth muscle contraction [UNKNOWN][IEA] negative regulation of heart contraction [UNKNOWN][IEA] regulation of the force of heart contraction [UNKNOWN][IEA] potassium ion transport [IDA] sodium ion transport [IDA] neurotransmitter uptake [UNKNOWN][IEA] regulation of muscle contraction [UNKNOWN] energy coupled proton transport, against electrochemical gradient [TAS] regulation of vasoconstriction [UNKNOWN][IEA]
Molecular Function:	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [IEA] cation-transporting ATPase activity [IMP] sodium:potassium-exchanging ATPase activity [UNKNOWN][IDA][TAS] monovalent inorganic cation transmembrane transporter activity [IEA] nucleotide binding [IEA] ATP binding [IEA][IMP] protein binding [UNKNOWN][IPI] potassium ion binding [TAS] catalytic activity [IEA] metal ion binding [IEA] sodium ion binding [TAS] hydrolase activity [IEA] hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG RKYQVDLSKG  60
   61 LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI LLWIGALLCF LAYGILAAME 120
  121 DEPSNDNLYL GIVLAAVVIV TGCFSYYQEA KSSKIMDSFK NMVPQQALVI REGEKMQINA 180
  181 EEVVVGDLVE VKGGDRVPAD LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI 240
  241 CFFSTNCVEG TARGIVIATG DRTVMGRIAT LASGLEVGQT PIAMEIEHFI QLITGVAVFL 300
  301 GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA RKNCLVKNLE 360
  361 AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT TEDQSGATFD KRSPTWTALS 420
  421 RIAGLCNRAV FKAGQENISV SKRDTAGDAS ESALLKCIEL SCGSVRKMRD RNPKVAEIPF 480
  481 NSTNKYQLSI HEREDSPQSH VLVMKGAPER ILDRCSTILV QGKEIPLDKE MQDAFQNAYM 540
  541 ELGGLGERVL GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV 600
  601 GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPREAKAC 660
  661 VVHGSDLKDM TSEQLDEILR DHTEIVFART SPQQKLIIVE GCQRQGAIVA VTGDGVNDSP 720
  721 ALKKADIGIA MGISGSDVSK QAADMILLDD NFASIVTGVE EGRLIFDNLK KSIAYTLTSN 780
  781 IPEITPFLLF IIANIPLPLG TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNSQTDK 840
  841 LVNERLISMA YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR TTNDLEDSYG 900
  901 QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLLEETA 960
  961 LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE VRKLILRRYP GGWVEKETYY1020
 1021

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: AT1A2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: