Protein Overview: C11B2_RAT

General Information:
Name(s) found:	C11B2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|A35342 steroid 11beta-monooxygenase (EC 1.14.15.4) 1 cytochrome P450 11B1 precursor - rat [NCBI NR] gi\|231898\|sp\|P30099.1\|C11B2_RAT RecName: Full=Cytochrome P450 11B2, mitochondrial; AltName: Full=CYPXIB2; AltName: Full=P450-Aldo-1; AltName: Full=Steroid 11-beta-hydroxylase; AltName: Full=Aldosterone synthase; Flags: Precursor [NCBI NR] gi\|220720\|dbj\|BAA00444.1\| cytochrome P-450 11beta, aldo precursor [Rattus norvegicus] [NCBI NR] ref\|NP_036669.1\| cytochrome P450, subfamily 11B, polypeptide 1 [Rattus norvegicus] [NCBI NR] (P30099) Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P450-Aldo-1) (Aldosterone synthase) [Swiss-Prot] Cytochrome P450 11B2, mitochondrial OS=Rattus norvegicus GN=Cyp11b2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Cytochrome P450 11B2, mitochondrial precursor [hmr_yeast5_DM3-1_pombe.fasta] cytochrome P450, subfamily 11B, polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); RATCP11BA; Cytochrome P450 subfamily XIB polypeptide 1 (steroid 11-beta-hydroxylase) [HMR_022704-rand.fasta] cytochrome P450, subfamily 11B, polypeptide 1 [Rattus norvegicus]gi\|220720\|dbj\|BAA00444.1\| cytochrome P-450 11beta, aldo precursor [Rattus norvegicus]gi\|92767\|pir\|\|A35342 steroid 11beta-monooxygenase (EC 1.14.15.4) 1 cytochrome P450 11B1 precursor - rat [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Cytochrome P450 11B2, mitochondrial precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012537) cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Cytochrome P450 11B2, mitochondrial precursor (CYPXIB2) (P450-Aldo-1) (Aldosterone synthase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cytochrome P-450 11beta, aldo precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Cyp11b2 Cytochrome P450 11B2, mitochondrial [rat-ipi-250309-contam.fasta] Cytochrome P450 11B2, mitochondrial OS=Rattus norvegicus GN=Cyp11b2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	510 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] mitochondrial membrane [IEA] mitochondrion [UNKNOWN][IEA] membrane [IEA]
Biological Process:	drinking behavior [UNKNOWN][IEA] response to salt stress [IEP] [NOT]cortisol biosynthetic process [UNKNOWN] potassium ion homeostasis [UNKNOWN] sodium ion homeostasis [UNKNOWN] steroid biosynthetic process [UNKNOWN] C21-steroid hormone biosynthetic process [UNKNOWN][IDA] response to peptide hormone stimulus [IEP] regulation of systemic arterial blood pressure by circulatory renin-angiotensin [UNKNOWN][IEA] positive regulation of blood pressure [IMP] regulation of blood volume by renal aldosterone [UNKNOWN][IEA] response to insulin stimulus [IEP] response to drug [IEP] aldosterone biosynthetic process [UNKNOWN][IEA] ion homeostasis [UNKNOWN][IEA] oxidation reduction [IEA]
Molecular Function:	metal ion binding [IEA] electron carrier activity [IEA] corticosterone 18-monooxygenase activity [IDA] steroid 11-beta-monooxygenase activity [UNKNOWN][IDA] monooxygenase activity [IEA] heme binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGACDNDFIE LHSRVTADVW LARPWQCLHR TRALGTTATL APKTLKPFEA IPQYSRNKWL  60
   61 KMIQILREQG QENLHLEMHQ AFQELGPIFR HSAGGAQIVS VMLPEDAEKL HQVESILPRR 120
  121 MHLEPWVAHR ELRGLRRGVF LLNGAEWRFN RLKLNPNVLS PKAVQNFVPM VDEVARDFLE 180
  181 ALKKKVRQNA RGSLTMDVQQ SLFNYTIEAS NFALFGERLG LLGHDLNPGS LKFIHALHSM 240
  241 FKSTTQLLFL PRSLTRWTST QVWKEHFDAW DVISEYANRC IWKVHQELRL GSSQTYSGIV 300
  301 AALITQGALP LDAIKANSME LTAGSVDTTA IPLVMTLFEL ARNPDVQQAL RQETLAAEAS 360
  361 IAANPQKAMS DLPLLRAALK ETLRLYPVGG FLERILNSDL VLQNYHVPAG TLVLLYLYSM 420
  421 GRNPAVFPRP ERYMPQRWLE RKRSFQHLAF GFGVRQCLGR RLAEVEMLLL LHHMLKTFQV 480
  481 ETLRQEDVQM AYRFVLMPSS SPVLTFRPIS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.86

Protein Overview: C11B2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: