Protein Overview: NEC2_RAT

General Information:
Name(s) found:	NEC2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981342\|ref\|NP_036878.1\| proprotein convertase subtilisin/kexin type 2 [Rattus norvegicus] [NCBI NR] pir\|\|KXRTC2 proprotein convertase 2 (EC 3.4.21.94) precursor - rat [NCBI NR] gi\|203511\|gb\|AAA40946.1\| hormone convertase [NCBI NR] gi\|149041251\|gb\|EDL95184.1\| proprotein convertase subtilisin/kexin type 2 [Rattus norvegicus] [NCBI NR] gi\|128004\|sp\|P28841.1\|NEC2_RAT RecName: Full=Neuroendocrine convertase 2; Short=NEC 2; AltName: Full=Prohormone convertase 2; AltName: Full=Proprotein convertase 2; Short=PC2; AltName: Full=KEX2-like endoprotease 2; Flags: Precursor [NCBI NR] Neuroendocrine convertase 2 OS=Rattus norvegicus GN=Pcsk2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):3-124944416;3-125099535 Neuroendocrine convertase 2 precursor [hmr_yeast5_DM3-1_pombe.fasta] proprotein convertase subtilisin/kexin type 2 [HMR_022704-rand.fasta] proprotein convertase subtilisin/kexin type 2 [Rattus norvegicus]gi\|67638\|pir\|\|KXRTC2 proprotein convertase 2 (EC 3.4.21.94) precursor - ratgi\|128004\|sp\|P28841\|NEC2_RAT Neuroendocrine convertase 2 precursor (NEC 2) (PC2) (Prohormone convertase 2) (Propr [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Neuroendocrine convertase 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012746) proprotein convertase subtilisin/kexin type 2 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Neuroendocrine convertase 2 precursor (NEC 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) (KEX2-like endoprotease 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] proprotein convertase subtilisin/kexin type 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] hormone convertase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 NEUROENDOCRINE CONVERTASE 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Neuroendocrine convertase 2 precursor (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Pcsk2 Neuroendocrine convertase 2 [rat-ipi-250309-contam.fasta] Neuroendocrine convertase 2 OS=Rattus norvegicus GN=Pcsk2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	637 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IEA] soluble fraction [UNKNOWN][IEA] secretory granule [IDA] membrane [UNKNOWN][IEA] cytoplasmic vesicle [IEA] transport vesicle [IEA]
Biological Process:	insulin processing [UNKNOWN][IEA] islet amyloid polypeptide processing [IMP] proteolysis [UNKNOWN][IMP] enkephalin processing [IEA] nervous system development [UNKNOWN][IEA] protein autoprocessing [IEA] peptide hormone processing [UNKNOWN][IMP]
Molecular Function:	protein binding [UNKNOWN][IPI] serine-type endopeptidase activity [UNKNOWN][IMP] peptidase activity [IEA] protein complex binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGGCGSQWK AAGLLFCVMV FASAERPVFT NHFLVELHKD GEEEARQVAA EHGFGVRKLP  60
   61 FAEGLYHFYH NGLAKAKRRR SLHHKRQLER DPRIKMALQQ EGFDRKKRGY RDINEIDINM 120
  121 NDPLFTKQWY LFNTGQADGT PGLDLNVAEA WELGYTGKGV TIGIMDDGID YLHPDLAYNY 180
  181 NSDASYDFSS NDPYPYPRYT DDWFNSHGTR CAGEVSAAAS NNICGVGVAY NSKVAGIRML 240
  241 DQPFMTDIIE ASSISHMPQL IDIYSASWGP TDNGKTVDGP RELTLQAMAD GVNKGRGGKG 300
  301 SIYVWASGDG GSYDDCNCDG YASSMWTISI NSAINDGRTA LYDESCSSTL ASTFSNGRKR 360
  361 NPEAGVATTD LYGNCTLRHS GTSAAAPEAA GVFALALEAN VDLTWRDMQH LTVLTSKRNQ 420
  421 LHDEVHQWRR NGVGLEFNHL FGYGVLDAGA MVKMAKDWKT VPERFHCVGG SVQNPEKIPP 480
  481 TGKLVLTLQT NACEGKENFV RYLEHVQAVI TVNATRRGDL NINMTSPMGT KSILLSRRPR 540
  541 DDDSKVGFDK WPFMTTHTWG EDARGTWTLE LGFVGSAPQK GLLKEWTLML HGTQSAPYID 600
  601 QVVRDYQSKL AMSKKQELEE ELDEAVERSL QSILRKN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NEC2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: