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Protein Overview: NMDE1_RAT

General Information:
Name(s) found: NMDE1_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Glutamate receptor ionotropic, NMDA 2A OS=Rattus norvegicus GN=Grin2a PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1464 amino acids

    Gene Ontology:
    Cellular Component: presynaptic membrane [IDA]
    postsynaptic density [UNKNOWN][IEA]
    synaptosome [UNKNOWN][IEA]
    synapse [UNKNOWN][TAS]
    neuron projection [IDA]
    plasma membrane [UNKNOWN][IMP]
    membrane fraction [UNKNOWN]
    postsynaptic membrane [UNKNOWN][IEA]
    membrane [IEA]
    dendritic spine [IDA]
    integral to membrane [IEA]
    cell junction [IEA]
    outer membrane-bounded periplasmic space [IEA]
    N-methyl-D-aspartate selective glutamate receptor complex [UNKNOWN][IDA]
    Biological Process: dopamine metabolic process [UNKNOWN][IEA]
    locomotion [UNKNOWN]
    protein localization [UNKNOWN][IEA]
    response to wounding [UNKNOWN][IEA]
    negative regulation of protein catabolic process [UNKNOWN][IEA]
    visual learning [UNKNOWN][IEA]
    neurogenesis [UNKNOWN][IEA]
    learning [UNKNOWN]
    memory [UNKNOWN][IDA]
    learning or memory [UNKNOWN]
    response to ethanol [UNKNOWN][IEA]
    ion transport [IEA]
    startle response [UNKNOWN][IEA]
    regulation of long-term neuronal synaptic plasticity [IMP]
    calcium ion transport [UNKNOWN][IEA]
    regulation of synaptic plasticity [IEA]
    regulation of action potential [IMP]
    directional locomotion [UNKNOWN][IEA]
    ionotropic glutamate receptor signaling pathway [IDA]
    regulation of postsynaptic membrane potential [UNKNOWN]
    serotonin metabolic process [UNKNOWN][IEA]
    regulation of excitatory postsynaptic membrane potential [UNKNOWN][IEA]
    synaptic transmission [UNKNOWN][IMP]
    regulation of membrane potential [UNKNOWN]
    response to amphetamine [UNKNOWN][IEA]
    rhythmic process [IDA]
    response to drug [UNKNOWN][IEA]
    positive regulation of apoptosis [UNKNOWN][IEA]
    sensory perception of pain [UNKNOWN]
    sleep [UNKNOWN][IEA]
    [NOT]detection of mechanical stimulus involved in sensory perception of pain [UNKNOWN]
    regulation of sensory perception of pain [UNKNOWN][IEA]
    Molecular Function: zinc ion binding [ISS]
    calcium channel activity [UNKNOWN][IEA]
    cation channel activity [UNKNOWN][IDA]
    cell adhesion molecule binding [IPI]
    neurotransmitter binding [IDA]
    voltage-gated cation channel activity [IMP]
    receptor activity [IEA]
    ionotropic glutamate receptor activity [IDA][IEA]
    extracellular-glutamate-gated ion channel activity [IEA][IMP]
    transporter activity [IEA]
    N-methyl-D-aspartate selective glutamate receptor activity [UNKNOWN][IDA][IMP]
    ion channel activity [IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    glutamate binding [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRLGYWTLL VLPALLVWRD PAQNAAAEKG PPALNIAVLL GHSHDVTERE LRNLWGPEQA  60
   61 TGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSQT 120
  121 FIPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 180
  181 RDFISFIKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 240
  241 SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGLGILT 300
  301 TAASSMLEKF SYIPEAKASC YGQAEKPETP LHTLHQFMVN VTWDGKDLSF TEEGYQVHPR 360
  361 LVVIVLNKDR EWEKVGKWEN QTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 420
  421 DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 480
  481 TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 540
  541 NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 600
  601 IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 660
  661 QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTRFNQ RGVEDALVSL 720
  721 KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFASTG YGIALQKGSP WKRQIDLALL 780
  781 QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 840
  841 FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 900
  901 AKNISNMSNM NSSRMDSPKR ATDFIQRGSL IVDMVSDKGN LIYSDNRSFQ GKDSIFGDNM 960
  961 NELQTFVANR HKDNLSNYVF QGQHPLTLNE SNPNTVEVAV STESKGNSRP RQLWKKSMES1020
 1021 LRQDSLNQNP VSQRDEKTAE NRTHSLKSPR YLPEEVAHSD ISETSSRATC HREPDNNKNH1080
 1081 KTKDNFKRSM ASKYPKDCSD VDRTYMKTKA SSPRDKIYTI DGEKEPSFHL DPPQFVENIT1140
 1141 LPENVGFPDT YQDHNENFRK GDSTLPMNRN PLHNEDGLPN NDQYKLYAKH FTLKDKGSPH1200
 1201 SEGSDRYRQN STHCRSCLSN LPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP1260
 1261 ATREEVYQQD WSQNNALQFQ KNKLRINRQH SYDNILDKPR EIDLSRPSRS ISLKDRERLL1320
 1321 EGNLYGSLFS VPSSKLLGNK SSLFPQGLED SKRSKSLLPD HASDNPFLHT YGDDQRLVIG1380
 1381 RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHS DVYISEHVMP YAANKNTMYS1440
 1441 TPRVLNSCSN RRVYKKMPSI ESDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle