Protein Overview: KSYK_RAT

General Information:
Name(s) found:	KSYK_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|975279\|gb\|AAA75167.1\| p72 [NCBI NR] gi\|6981620\|ref\|NP_036890.1\| spleen tyrosine kinase [Rattus norvegicus] [NCBI NR] gi\|3219819\|sp\|Q64725.1\|KSYK_RAT RecName: Full=Tyrosine-protein kinase SYK; AltName: Full=Spleen tyrosine kinase [NCBI NR] Tyrosine-protein kinase SYK OS=Rattus norvegicus GN=Syk PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):17-20888897;17-20888897 Splice isoform SykB of Q64725 [hmr_yeast5_DM3-1_pombe.fasta] spleen tyrosine kinase [HMR_022704-rand.fasta] spleen tyrosine kinase [Rattus norvegicus]gi\|3219819\|sp\|Q64725\|KSYK_RAT Tyrosine-protein kinase SYK (Spleen tyrosine kinase)gi\|975279\|gb\|AAA75167.1\| p72 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform SykB of Tyrosine-protein kinase SYK [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012758) spleen tyrosine kinase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tyrosine-protein kinase SYK (Spleen tyrosine kinase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] spleen tyrosine kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] p72 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF TYROSINE-PROTEIN KINASE SYK [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Syk Isoform SykB of Tyrosine-protein kinase SYK [rat-ipi-250309-contam.fasta] Isoform SykB of Tyrosine-protein kinase SYK OS=Rattus norvegicus GN=Syk [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	629 amino acids
Gene Ontology:
Cellular Component:	B cell receptor complex [UNKNOWN][IEA] cytoplasm [IEA] T cell receptor complex [UNKNOWN][IEA]
Biological Process:	peptidyl-tyrosine phosphorylation [UNKNOWN] positive regulation of mast cell degranulation [UNKNOWN][IMP] positive regulation of interleukin-3 biosynthetic process [UNKNOWN][IEA] positive regulation of gamma-delta T cell differentiation [UNKNOWN][IEA] activation of JUN kinase activity [UNKNOWN][IEA] protein amino acid autophosphorylation [UNKNOWN][IDA][IEA] cell surface receptor linked signaling pathway [UNKNOWN] enzyme linked receptor protein signaling pathway [UNKNOWN][IEA] beta selection [UNKNOWN][IEA] positive regulation of alpha-beta T cell differentiation [UNKNOWN][IEA] leukocyte cell-cell adhesion [UNKNOWN][IEA] positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [UNKNOWN][IEA] positive regulation of B cell differentiation [UNKNOWN][IEA] positive regulation of calcium-mediated signaling [UNKNOWN][IEA] activation of MAPK activity [UNKNOWN] serotonin secretion [UNKNOWN][IEA] leukotriene biosynthetic process [UNKNOWN][IEA] intracellular signaling pathway [UNKNOWN][IEA] positive regulation of alpha-beta T cell proliferation [UNKNOWN][IEA] neutrophil chemotaxis [UNKNOWN][IEA] positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA] regulation of immune response [IDA] B cell receptor signaling pathway [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [UNKNOWN][IEA] protein tyrosine kinase activity [UNKNOWN] protein domain specific binding [IMP] protein binding [UNKNOWN][IEA][IPI] non-membrane spanning protein tyrosine kinase activity [UNKNOWN][IEA] receptor signaling protein tyrosine kinase activity [UNKNOWN][IEA] protein kinase activity [IDA] integrin binding [UNKNOWN][IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNAVDNAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA  60
   61 HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPEGLVC LLKKPFNRPP GVQPKTGPFE 120
  121 DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT 180
  181 VLIGSKTNGK FLIRARDNNG SFALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV 240
  241 EHYSYKPDGL LRVLTVPCQK IGVQMGHPGS SNAHPVTWSP GGIISRIKSY SFPKPGHKKP 300
  301 PPPQGSRPES TVSFNPYEPT GGAWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD 360
  361 RKLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ 420
  421 LDNPYIVRMI GICEAESWML VMEMAAWGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE 480
  481 ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY 540
  541 FKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPPG CPREMYDLMF 600
  601 LCWTYDVENR PGFAAVELRL RNYYYDVVN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: KSYK_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: