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Protein Overview: FKB1A_RAT

General Information:
Name(s) found: FKB1A_RAT [Swiss-Prot]
Description(s) found:
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  • gi|501064|gb|AAA19163.1| immunophilin FKBP12 [NCBI NR]
  • gi|47271544|ref|NP_037234.2| FK506 binding protein 1A, 12kDa [Rattus norvegicus] [NCBI NR]
  • gi|47125443|gb|AAH70519.1| FK506-binding protein 1a [Rattus norvegicus] [NCBI NR]
  • gi|2499772|sp|Q62658.3|FKB1A_RAT RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP1A; Short=PPIase FKBP1A; AltName: Full=FK506-binding protein 1A; Short=FKBP-1A; AltName: Full=Rotamase; AltName: Full=Immunophilin FKBP12; Short=12 kDa FKBP; Short=FKBP [NCBI NR]
  • ref|NP_445760.1| FK506 binding protein 2 [Rattus norvegicus] [NCBI NR]
  • gi|1568633|gb|AAB48933.1| FKBP12 [Rattus norvegicus] [NCBI NR]
  • gi|149031093|gb|EDL86120.1| FK506 binding protein 1a, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149031089|gb|EDL86116.1| FK506 binding protein 1a, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|127799555|gb|AAH70519.3| FK506 binding protein 1a [Rattus norvegicus] [NCBI NR]
  • gi|117558333|gb|AAI26072.1| FK506 binding protein 1a [Rattus norvegicus] [NCBI NR]
  • Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Rattus norvegicus GN=Fkbp1a PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):3-134629150 FK506 binding protein 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • FK506 binding protein 2; FK506 binding protein 2 (13 kDa) [HMR_022704-rand.fasta]
  • FK506-binding protein 1a; FK506-binding protein 1 (12kD); immunophilin FKBP12 [071204_hmrz_cont.fasta]
  • FK506-binding protein 1a [Rattus norvegicus]gi|17985953|ref|NP_445760.1| FK506 binding protein 2 [Rattus norvegicus]gi|47125443|gb|AAH70519.1| FK506-binding protein 1a [Rattus norvegicus]gi|1568633|gb|AAB48933.1| FKBP12 [Rattus norvegicus]gi|2499772|s [nrdb_11152004_Chlamydomonas]
  • (NM_053308) FK506 binding protein 2; FK506 binding protein 2 (13 kDa) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • FK506-binding protein 1A (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (Immunophilin FKBP12) (12 kDa FKBP) (FKBP-12) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FK506 binding protein 1a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FK506 binding protein 1a, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FKBP12 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • immunophilin FKBP12 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 FK506-BINDING PROTEIN 1A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • FK506 binding protein 1A, 12kDa [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • FK506-binding protein 1a [Rattus norvegicus] [nr-271106-contam.fasta]
  • FK506-binding protein 1A (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (12 kDa FKBP) (FKBP-12) (Immunophilin FKBP12) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A [rat-ipi-250309-contam.fasta]
  • peptidyl-prolyl cis-trans isomerase FKBP1A [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Rattus norvegicus GN=Fkbp1a [011711_HMR.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Rattus norvegicus GN=Fkbp1a PE=2 SV=3 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 108 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN]
    cytoplasm [IEA]
    microsome [IDA]
    cytosol [UNKNOWN]
    axon terminus [IDA]
    sarcoplasmic reticulum membrane [UNKNOWN]
    Biological Process: SMAD protein complex assembly [UNKNOWN]
    positive regulation of protein binding [UNKNOWN]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN]
    protein folding [IEA]
    fibril organization [UNKNOWN]
    regulation of ryanodine-sensitive calcium-release channel activity [UNKNOWN]
    regulation of activin receptor signaling pathway [UNKNOWN]
    negative regulation of protein amino acid phosphorylation [UNKNOWN]
    muscle contraction [UNKNOWN]
    cytokine-mediated signaling pathway [UNKNOWN]
    T cell proliferation [UNKNOWN]
    response to iron ion [IEP]
    positive regulation of protein ubiquitination [UNKNOWN]
    response to caffeine [UNKNOWN]
    release of sequestered calcium ion into cytosol [UNKNOWN]
    negative regulation of protein phosphatase type 2B activity [UNKNOWN]
    beta-amyloid formation [UNKNOWN]
    regulation of immune response [UNKNOWN]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IDA]
    activin binding [UNKNOWN]
    drug binding [UNKNOWN]
    SMAD binding [UNKNOWN]
    transforming growth factor beta receptor binding [IDA]
    FK506 binding [UNKNOWN][IDA]
    signal transducer activity [UNKNOWN]
    type I transforming growth factor beta receptor binding [IDA]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVQVETISS GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT LGKQEVIRGW  60
   61 EEGVAQMSVG QRAKLIISPD YAYGATGHPG IIPPHATLVF DVELLKLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 36.69897 ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle